临床传统医学和药理学（英文）2026，Vol.7Issue(2)：78-87,10.DOI:10.1016/j.ctmp.2026.200282
两种添加西地那非的传统传统壮阳制剂(Attoté和Congnons-moussos)慢性暴露诱导Wistar大鼠睾丸毒性
Testicular toxicity induced by chronic exposure to two adulterated traditional aphrodisiacs named Attoté and Congnons-moussos containing sildenafil in wistar rats
Basile Tindano 1Abdoul Karim Sakira 2Sie Abel Flavien Ouedraogo 2Elisabeth Ouedraogo 1Balé Bayala1
作者信息
- 1. Animal Physiology Laboratory,Joseph Ki-Zerbo University,Ouagadougou BP 7021,Burkina Faso
- 2. Laboratory of Toxicology,Environment and Health,Joseph Ki-Zerbo University,Ouagadougou BP 7021,Burkina Faso
- 折叠
摘要
Abstract
Background:The uncontrolled consumption of traditional herbal aphrodisiacs adulterated with pharmacologically active substances such as sildenafil represents a growing public health concern in regions where these products are widely used without medical supervision.
Objective:This study aimed to evaluate the testicular toxicity induced by chronic oral exposure to two traditional aphrodisiac formulations adulterated with sildenafil in male Wistar rats.
Methods:Male Wistar rats were orally administered distilled water(control),5 mg/kg body weight(bw)of sildenafil citrate,or one of two sildenafil-adulterated aphrodisiac formulations named Attoté(AT)and Congnons-moussos(CM)at doses of 50 mg/kg bw,100 mg/kg bw,and 200 mg/kg bw for 90 consecutive days.Testicular tox-icity was assessed through measurements of hormones(testosterone,follicle-stimulating hormone(FSH),luteiniz-ing hormone(LH)),biochemical parameters(cholesterol,total protein,alkaline phosphatase(ALP),gamma-glutamyl transferase(GGT),oxidative stress biomarkers(malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT),reduced glutathione(GSH),glutathione peroxidase(GPx)),as well as histopathological examina-tion of testicular tissue.
Results:Chronic exposure to the adulterated aphrodisiac formulations induced a dose-dependent reduction in relative testicular weight and serum testosterone levels,particularly in rats receiving the highest dose of CM.Significant elevations in FSH and LH concentrations were observed at higher doses,concomitant with marked oxidative stress characterized by increased MDA levels and decreased antioxidant enzyme activities.Histological analysis revealed severe degenerative alterations of the seminiferous tubules in groups treated with high doses.
Conclusion:These findings demonstrate that chronic consumption of sildenafil-adulterated traditional aphrodisi-acs induces significant testicular toxicity through endocrine disruption,oxidative stress,and structural degener-ation of testicular tissue.关键词
草本壮阳制剂/西地那非添加/睾丸毒性/氧化应激/Wistar大鼠Key words
Herbal aphrodisiac/Sildenafil adulteration/Testicular toxicity/Oxidative stress/Wistar rats引用本文复制引用
Basile Tindano,Abdoul Karim Sakira,Sie Abel Flavien Ouedraogo,Elisabeth Ouedraogo,Balé Bayala..两种添加西地那非的传统传统壮阳制剂(Attoté和Congnons-moussos)慢性暴露诱导Wistar大鼠睾丸毒性[J].临床传统医学和药理学（英文）,2026,7(2):78-87,10.
