西南医科大学学报2026，Vol.49Issue(4)：426-431,6.DOI:10.3969/j.issn.2096-3351.2026.04.003
DNA甲基化在肿瘤心脏病中的潜在调控作用及干预前景
Potential Regulatory Roles of DNA Methylation in Cardio-Oncology and Prospects for Intervention
摘要
Abstract
Cardio-oncology is an emerging interdisciplinary field that primarily focuses on the occurrence,progression,and treatment of cardiovascular diseases in cancer patients.Advances in both basic and clinical oncology have steadily reduced cancer-related mortality,resulting in increased survival in cancer patients.As a result,cardiovascular disease has become the leading cause of death in this population.Therefore,understanding the underlying mechanisms of cardiovascular complications and identifying effective therapeutic targets have become a critical challenge in improving long-term health and quality of life in cancer survivors.The pathogen-esis of cancer-related heart disease is complex.Among the various potential mechanisms driving the development of cardiovascular dis-eases in cancer patients,tumor suppressor gene promoter hypermethylation plays a critical role.Studies have shown that the genomes of cancer patients commonly exhibit global hypomethylation and abnormal hypermethylation of tumor suppressor genes.A deeper under-standing of the role of DNA methylation in cancer patients may offer new perspectives and directions for the prevention and treatment of cardiovascular diseases in cancer patients.关键词
肿瘤心脏病学/DNA甲基化/表观遗传调控/心血管疾病Key words
Cardio-oncology/DNA methylation/Epigenetic regulation/Cardiovascular disease分类
医药卫生引用本文复制引用
刘静怡,陈馨意,裴梨君,肖馨怡,党喜同,毛亮..DNA甲基化在肿瘤心脏病中的潜在调控作用及干预前景[J].西南医科大学学报,2026,49(4):426-431,6.基金项目
国家自然科学基金面上项目(81770336) （81770336）
四川省自然科学基金面上项目(2025ZNSFSC0711,2024NSFSC0582) （2025ZNSFSC0711,2024NSFSC0582）
四川省大学生创新创业项目(S202310632143,S202510632219) （S202310632143,S202510632219）
