西南医科大学学报2026，Vol.49Issue(4)：442-447,6.DOI:10.3969/j.issn.2096-3351.2026.04.005
靶向保护内皮糖萼为脓毒性心肌病提供新治疗策略
Targeted Protection of the Endothelial Glycocalyx Presents a Novel Therapeutic Strategy for Septic Cardiomyopathy
摘要
Abstract
Septic cardiomyopathy is an infectious heart disease with a high mortality rate in the acute phase.The endothelial gly-cocalyx(EG)is an important structure that covers the surface of vascular endothelial cells.Composed of proteoglycans,glycoproteins,and other macromolecules,it plays a critical role in maintaining the barrier function of endothelial cells and protecting the structural integrity of the endothelium.Studies have shown that the activation of immune cells caused by sepsis is closely related to the metabolism of EG,which can lead to its structural shedding and degradation.Therefore,protective strategies against EG may provide a new direc-tion for drug therapy in septic cardiomyopathy.The purpose of this paper is to review the physiological structure of EG,its key role in the pathogenesis of septic cardiomyopathy,and its related mechanism to the production of inflammatory factors.In addition,this review includes treatment options around EG production,such as enzymatic therapy,supplementation of endothelial glycocalyx components,and treatment of nanomaterials.关键词
脓毒性心肌病/内皮糖萼/炎症/转化医学/血管内皮细胞黏附-微循环Key words
Septic cardiomyopathy/Endothelial glycocalyx/Inflammation/Translational medicine/Vascular endothelial cell attachment-microcirculation分类
医药卫生引用本文复制引用
杨凯,王禹,李诚,袁琼..靶向保护内皮糖萼为脓毒性心肌病提供新治疗策略[J].西南医科大学学报,2026,49(4):442-447,6.基金项目
国家自然科学基金(82370359) （82370359）
四川省科技计划项目(2024NSFTD0028,2022YFS0607) （2024NSFTD0028,2022YFS0607）
