西南医科大学学报2026，Vol.49Issue(4)：467-471,5.DOI:10.3969/j.issn.2096-3351.2026.04.009
腹膜透析患者血清胎球蛋白A、NLRP3和sCD14水平的交互性及对血管钙化的诊断价值
Interactions Among Serum Fetuin-A,NLRP3,and sCD14 Levels in Peritoneal Dialysis Patients and Their Diagnostic Value for Vascular Calcification
摘要
Abstract
Objective To investigate changes in serum Fetuin-A,NLRP3,and sCD14 levels in peritoneal dialysis patients,and to analyze their interactions and diagnostic value for vascular calcification.Methods The 253 peritoneal dialysis patients were divided into the occurrence group(84 cases)and the non-occurrence group(169 cases)according to the presence of vascular calcifica-tion,and 253 healthy individuals in the same period were selected as the control group.The serum levels of Fetuin-A,NLRP3,and sCD14 were compared between the dialysis and control groups,as well as between the occurrence and non-occurrence groups.Pearson correlation analysis was used to assess the relationships between serum sCD14,Fetuin-A,NLRP3,and vascular calcification.The interactions among serum Fetuin-A,NLRP3,and sCD14 levels were analyzed using an additive model.ROC curves were used to evalu-ate the predictive value of these markers for vascular calcification.Results Compared with the control group,the dialysis group exhib-ited elevated NLRP3 and sCD14 levels,along with decreased Fetuin-A levels(P<0.05).Compared with the non occurrence group,the level of Fetuin-A in the occurrence group decreased and the levels of NLRP3 and sCD14 increased(P<0.05).Pearson results showed that the levels of NLRP3 and sCD14 were positively correlated with vascular calcification,and there was a negative correlation between Fetuin-A and vascular calcification(P<0.05).When sCD14 and NLRP3 were co-exposed,the relative excess risk due to interaction(RERI)was 60.254,the attributable proportion due to interaction(API)was 74.438,and the synergy index(S)was 4.497.When Fetuin-A and NLRP3 were co-exposed,the RERI was 2.738,the API was 15.294,and the S was 1.243.When Fetuin-A and sCD14 were co-exposed,the RERI was 2.879,the API was 14.325,and the S was 1.204.ROC curve analysis indicated that the combined use of Fetuin-A,NLRP3,and sCD14 demonstrated higher diagnostic efficacy than any single marker alone.Conclusion Fetuin-A,NLRP3,and sCD14 exhibited additive interactions in peritoneal dialysis patients,and simultaneous exposure to all three increased the risk of vascular calcification.Combined testing enhanced diagnostic efficiency for vascular calcification.关键词
腹膜透析/胎球蛋白A/NOD样受体蛋白3/可溶性CD14/血管钙化Key words
Peritoneal dialysis/Fetuin-A/NOD-like receptor protein 3/Soluble CD14/Vascular calcification分类
医药卫生引用本文复制引用
鲍妍,王云,王树龙,张连云,刘向东..腹膜透析患者血清胎球蛋白A、NLRP3和sCD14水平的交互性及对血管钙化的诊断价值[J].西南医科大学学报,2026,49(4):467-471,5.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20220591) （LHGJ20220591）
