生物医学工程研究2026，Vol.45Issue(3)：227-233,7.DOI:10.19529/j.cnki.1672-6278.2026.03.07
外消旋聚乳酸可吸收隔离膜的静电纺丝工艺及性能研究
Electrospinning process and performance study of poly(D,L-lactic acid)absorbable barrier membranes
摘要
Abstract
To explore the potential application of poly(D,L-lactic acid)(PDLLA)in tissue repair,we used PDLLA as the sub-strate material and prepared the precursor solution by mixing chloroform and N,N-dimethylformamide(CF/DMF)as the solvent.PDL-LA absorbable barrier membranes were fabricated via the electrospinning process.The membrane exhibited a most probable pore size of 1.08 μm and porosity of 64.6%,which could provide appropriate channels for the transport of nutrients and excretion of metabolites.Mechanical test results showed that the membrane had a tensile strength of up to 7.09 MPa,elongation at break of 129%,and tearing force of 4.39 N,which could meet the mechanical requirements for tissue barrier membranes.In vitro degradation experiments con-firmed that the PDLLA membrane could maintain stable mechanical properties within a 3-month degradation period,ensuring the sus-tained and effective performance of the tissue isolation function.This study can provide a basis for the clinical application of PDLLA ab-sorbable isolation membranes.关键词
消旋聚乳酸/静电纺丝/纳米纤维/微观形貌/力学性能Key words
Poly(D,L-lactic acid)/Electrospinning/Nano-fibers/Micro-morphology/Mechanical properties分类
医药卫生引用本文复制引用
朱爱臣,马丽霞,李文明,史建华,朱肖杰,赵瑾,张宪科,刘阳,石锐..外消旋聚乳酸可吸收隔离膜的静电纺丝工艺及性能研究[J].生物医学工程研究,2026,45(3):227-233,7.基金项目
济南市"新高校20条"资助项目引进创新团队(202333029). （202333029）
