无机材料学报2026，Vol.41Issue(6)：839-846,8.DOI:10.15541/jim20250319
锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护
Enhanced ROS Scavenging Property of Polyoxometalates by Manganese Doping for Cytoprotection
摘要
Abstract
Excessive accumulation of reactive oxygen species(ROS)can trigger oxidative stress in cells,ultimately leading to cell death.Nanozymes,a class of nanomaterials with enzyme-like catalytic activity,are capable of scavenging ROS and protecting cells from oxidative damage.Polyoxometalates(POMs),known for their favorable redox properties and biocompatibility,have been considered as potential nanozyme candidates.However,their relatively low catalytic activity has hindered their practical applications.In this study,an isomorphic doping strategy with manganese(Mn)was employed to effectively enhance the enzyme-like activity of Keggin-type POMs([PMo12O40]3-).It was found that appropriate Mn doping significantly improved both the catalase-like(CAT-like)and superoxide dismutase-like(SOD-like)activities of the POMs,thereby enhancing its ability to eliminate excessive ROS and protect cells from oxidative stress-induced damage.The relationships among Mn doping levels,POMs structure,and catalytic activity were systematically investigated.The results suggest that the synergistic electronic interaction between Mn and Mo-O framework plays a crucial role in enhancing the CAT-like activity of the material.This work provides a preliminary exploration of design strategies for POMs-based nanozymes and offers scientific insights for the development of antioxidant nanozymes.关键词
多金属氧酸盐/氧化应激/纳米酶/催化医学Key words
polyoxometalate/oxidative stress/nanozyme/catalytic medicine分类
化学化工引用本文复制引用
曲博渲,谭继,陈书寒,刘宣勇..锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护[J].无机材料学报,2026,41(6):839-846,8.基金项目
National Key Research and Development Program of China(2022YFC2403000) （2022YFC2403000）
