中国畜牧杂志2026，Vol.62Issue(7)：51-61,11.DOI:10.19556/j.0258-7033.20250528-04
哺乳动物卵母细胞玻璃化冷冻中抗氧化剂对活性氧的调控作用研究进展
Advances in the Regulation of Reactive Oxygen Species by Antioxidants during Vitrification of Mammalian Oocytes
摘要
Abstract
Excessive accumulation of reactive oxygen species(ROS)during the vitrification of mammalian oocytes induces oxidative stress,severely impairing the structural integrity and functional competence of the oocytes.This oxidative damage has become a major bottleneck limiting post-thaw survival rates and developmental potential.Antioxidants can effectively alleviate oxidative injury by scavenging excessive ROS and enhancing the structure and function of endogenous antioxidant systems,thereby improving the efficiency of oocyte cryopreservation.This review article systematically summarizes the sources and mechanisms of ROS-induced damage during oocyte vitrification,including lipid peroxidation,protein misfolding,mitochondrial dysfunction,and activation of apoptotic signaling pathways.Furthermore,it explores the mechanisms by which different types of antioxidants regulate ROS and evaluates their efficacy in the vitrification of oocytes.The aim is to provide new insights for the development of more effective cryoprotective strategies.关键词
卵母细胞/玻璃化冷冻/活性氧(ROS)/抗氧化剂Key words
Oocyte/Vitrification/Reactive Oxygen Species(ROS)/Antioxidant分类
农业科技引用本文复制引用
曹植虹,肖霖力,刘彦,白佳桦,秦玉圣,刘克雄,杨凌,许晓玲..哺乳动物卵母细胞玻璃化冷冻中抗氧化剂对活性氧的调控作用研究进展[J].中国畜牧杂志,2026,62(7):51-61,11.基金项目
"十四五"国家重点研发计划项目(2021YFD1200402) （2021YFD1200402）
北京市农林科学院创新能力建设项目(KJCX20230218) （KJCX20230218）
北京市农林科学院农业科技示范服务项目(2025SFFW-SFJD-027) （2025SFFW-SFJD-027）
