癌变·畸变·突变2026，Vol.38Issue(4)：310-315,330,7.DOI:10.3969/j.issn.1004-616x.2026.04.008
醋鳖甲的毒理学安全性试验研究
The toxicological safety tests of vinegar turtle shell
摘要
Abstract
OBJECTIVE:To study toxicity of vinegar turtle shell.METHODS:Toxicity of vinegar turtle shell was tested according to Procedures and Methods for Toxicological Evaluation of Food Safety(GB 15193).The following tests were conducted:acute oral toxicity test,Ames test,micronucleus test of mouse bone marrow red blood cells,chromosome aberration test of mouse spermatocyte and 28-day oral toxicity test.RESULTS:The half of lethal dose(LD50)values of male and female mice in the acute oral toxicity test were greater than 20.0 g/kg,which was classified as practically non-toxic.The results of Ames test,micronucleus test of mouse bone marrow red blood cells and chromosome aberration test of mouse spermatocyte were all negative.In the 28-day oral toxicity test,no significant changes were observed in total weight gain,total food intake,eye,hematology,blood biochemistry,urine and histopathology of rats in the 3 dose groups of 20,10 and 5 g/kg compared with the control group(P>0.05).CONCLUSION:Under the conditions of this experiment,the vinegar turtle shell showed no acute toxicity or genetic toxicity.It belongs to the non-toxic food raw materials.关键词
醋鳖甲/遗传毒性/急性毒性/Ames试验/28天经口毒性Key words
vinegar turtle shell/genotoxicity/acute toxicity/Ames test/28-day oral toxicity分类
医药卫生引用本文复制引用
杨娜娜,李维,张帆,崔坚..醋鳖甲的毒理学安全性试验研究[J].癌变·畸变·突变,2026,38(4):310-315,330,7.基金项目
陕西省重点研发计划项目(2024NC-YBXM-137) （2024NC-YBXM-137）
