癌变·畸变·突变2026，Vol.38Issue(4)：316-320,5.DOI:10.3969/j.issn.1004-616x.2026.04.009
生育三烯酚富集组分的急性经口毒性和遗传毒性评价
Acute oral toxicity and genotoxicity assessment on tocotrienol-rich fraction
胡培丽 1张励 1刘婷 1郑济凡 1刘师卜 1单纯 2李波1
作者信息
- 1. 中国食品药品检定研究院,北京 102629
- 2. 北京市药品检验研究院,北京 102206
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate acute oral toxicity and genotoxicity of tocotrienol-rich fraction(TRF).METHODS:According to the national food safety standards,toxicity grade of TRF was evaluated using an acute oral toxicity test.Genotoxicity was assessed using a bacterial reverse mutation test,a mammalian erythrocyte micronucleus test,and a mouse spermatocyte chromosomal aberration test.RESULTS:The acute oral median lethal dose(LD50)of TRF in mice was greater than 19.4 g/kg,classifying it as non-toxic.In the bacterial reverse mutation test,the number of revertant colonies in two independent experiments(with and without S9 metabolic activation)did not exceed twice the background spontaneous mutation rate,and no dose-response relationship was observed,indicating a negative result.In the mammalian erythrocyte micronucleus test,doses of 2.5,5.0 and 10.0 g/kg TRF did not induce a significant increase in the micronucleus rate of mouse bone marrow polychromatic erythrocytes(P>0.05).In the mouse spermatocyte chromosome aberration test,no significant increases in the chromosome aberration rate or the percentage of aberrant cells were observed at any dose levels(P>0.05).CONCLUSION:Under the conditions of this study,TRF can be classified as non-toxic and it shows no evidence of genotoxicity.关键词
生育三烯酚富集组分/急性毒性/遗传毒性/小鼠Key words
tocotrienol-rich fraction/acute toxicity/genotoxicity/mice分类
医药卫生引用本文复制引用
胡培丽,张励,刘婷,郑济凡,刘师卜,单纯,李波..生育三烯酚富集组分的急性经口毒性和遗传毒性评价[J].癌变·畸变·突变,2026,38(4):316-320,5.
