北京中医药2026，Vol.45Issue(5)：569-573,5.DOI:10.16025/j.1674-1307.2026.05.001
清热化湿颗粒联合西药治疗老年幽门螺杆菌感染的疗效评价
Clinical efficacy evaluation of Qingre Huashi Granules combined with conventional Western medicine in treating Helicobacter pylori infection in elderly patients
摘要
Abstract
Objective To investigate whether the combination of the clinical empirical formula Qingre Huashi Granules and Western medicine can achieve a clinically satisfactory Helicobacter pylori(HP)eradication rate while further improving dyspeptic symptoms.Methods A retrospective study was conducted involving 160 patients.The composite success rate 4 weeks after completion of medication was evaluated,defined as the proportion of patients achieving both HP eradication and a≥30%improvement in the Gastrointestinal Symptom Score Scale(GOSS)score.In addition,the distribution characteristics of clinical symptom clusters in elderly patients with HP infection and the correlation between the efficacy index of the spleen-stomach dampness-heat syndrome and the GOSS score improvement rate were analyzed.Results The composite success rates were 46.25%in the observation group and 51.25%in the control group,with no statistically significant difference between the two groups(P=0.527).Clinical symptoms in elderly patients with HP infection could be classified into three major clusters.The acid reflux-heartburn cluster had the highest positive rate(43.19%),followed by the early satiety-postprandial fullness cluster(34.69%)and the nausea-belching cluster(31.25%).Correlation analysis showed that the efficacy index of the spleen-stomach dampness-heat syndrome was positively correlated with the GOSS score improvement rate(r=0.28,P=0.002).Conclusion The Qingre Huashi dual therapy can help improve dyspeptic symptoms in elderly patients while eradicating HP,and is worthy of clinical application.关键词
幽门螺杆菌/二联疗法/清热化湿颗粒/临床疗效Key words
Helicobacter pylori/dual therapy/Qingre Huashi Granules/clinical efficacy引用本文复制引用
陈雪靓,陈瑶,王英旭,张学智,王自成,叶晖,杨闪闪,黄秋月,贾晓芬,沈姝玥,曹峻文,王绍华..清热化湿颗粒联合西药治疗老年幽门螺杆菌感染的疗效评价[J].北京中医药,2026,45(5):569-573,5.基金项目
首都卫生发展科研专项——自主创新项目(首发2022-2-40711) （首发2022-2-40711）
北京大学第一医院种子基金课题(2023SF25,2024SF49) （2023SF25,2024SF49）
山西省中医药管理局中医药创新团队建设计划项目(zyytd2024030) （zyytd2024030）
国家中医药管理局中医传承与创新"百千万"人才工程(岐黄工程)——国家中医药领军人才支撑计划项目(国中医人教函[2022]6号) （岐黄工程）
中央高水平医院临床科研业务费资助(北京大学第一医院科研种子基金)项目(2024SF87) （北京大学第一医院科研种子基金）
