川北医学院学报2026，Vol.41Issue(8)：934-937,4.DOI:10.3969/j.issn.1005-3697.2026.08.006
布比卡因脂质体行PENG与LFCN联合阻滞对老年全髋关节置换术患者术后应激和认知功能的影响
Effects of PENG+LFCN block with bupivacaine liposome on stress and cognitive function in elderly patients after total hip arthroplasty
摘要
Abstract
Objective:To explore the effects of pericapsular nerve group(PENG)and lateral femoral cutaneous nerve(LF-CN)block with bupivacaine liposome(LB)on stress and cognitive function in elderly patients after total hip arthroplasty.Methods:According to different intervention methods,100 elderly patients undergoing total hip arthroplasty were divided into observation group(n=50,PENG+LFCN block with LB)and control group(n=50,PENG+LFCN block with ropivacaine).The postoperative analgesia,stress response,cognitive function,recovery and adverse reactions were compared between the two groups.Results:At 12,24 and 48 h after surgery,VAS scores under rest and motion states,and compression frequency of patient controlled intravenous analgesia(PCIA)in observation group were lower than those in control group(P<0.05).At 1 d after surgery,levels of cortisol(COR),adrenaline(N)and norepinephrine(NE)in observation group were lower than those in control group(P<0.05).At 3 and 7 d after surgery,scores of mini-mental state examination(MMSE)in observation group were higher than those in control group(P<0.05).The first leaving bed time and length of hospital stay in observation group were shorter than those in control group(P<0.05).Conclusion:Compared with ropivacaine,PENG+LFCN block with LB has better analgesic effect in elderly patients after total hip arthroplasty,which can alleviate postoperative stress response,protect cognitive function and promote recovery.关键词
全髋关节置换术/老年/布比卡因脂质体/髋关节囊周围神经阻滞/股外侧皮神经阻滞/应激反应/认知功能Key words
Total hip arthroplasty/Elderly/Bupivacaine liposome/Pericapsular nerve group/Lateral femoral cutaneous nerve block/Stress response/Cognitive function分类
医药卫生引用本文复制引用
谢玉海,张利亮,惠庭旗玉..布比卡因脂质体行PENG与LFCN联合阻滞对老年全髋关节置换术患者术后应激和认知功能的影响[J].川北医学院学报,2026,41(8):934-937,4.基金项目
青海省卫生健康系统指导性计划项目(2022-wjzdx-83) （2022-wjzdx-83）
