川北医学院学报2026，Vol.41Issue(8)：943-947,5.DOI:10.3969/j.issn.1005-3697.2026.08.008
核转录因子κB、多肿瘤抑制基因与宫颈癌临床特征及放疗敏感性的关系
Relationship between nuclear factor-kappa B,multiple tumor suppressor gene and clinical features of cervical cancer and sensitivity to radiotherapy
摘要
Abstract
Objective:To investigate the relationship between nuclear factor-kappa B(NF-κB),multiple tumor suppressor gene(P16)and clinical features of cervical cancer as well as sensitivity to radiotherapy.Methods:Retrospective collection of clinical data from 119 patients with cervical cancer.All patients were tested for the positive expression of NF-κB and P16 in cervical cancer cells.The relationship between their expression and clinical features as well as sensitivity to radiotherapy was analyzed.Results:Among the 119 specimens,88(73.95%)were positive for NF-κB and 97(81.51%)were positive for P16.The positive expression rates of NF-κB and P16 showed significant differences between patients with varying degrees of differentiation and patients with/without lymph node metastasis(P<0.05).Spearman correlation analysis revealed that the positive expression rate of NF-κB was positively correlated with the degree of differentiation and lymph node metastasis(P<0.05),whereas the positive expression rate of P16 was negatively correlated with these clinical features(P<0.05).Univariate and multivariate Logistic regression analyses indicated that lymph node metastasis and NF-κB positivity were independent risk factors for insensitivity to radiotherapy,whereas P16 positivity was an independent protective factor against(P<0.05).Conclusion:NF-κB and P16 are closely related to the degree of differentiation and lymph node metastasis in cervical cancer.The positive expression of NF-κB and the positive expression of P16 are influencing factors for insensitivity to radiotherapy.关键词
核转录因子κB/多肿瘤抑制基因/宫颈癌/临床特征/化疗敏感性Key words
Nuclear factor-kappa B/Multiple tumor suppressor gene/Cervical cancer/Clinical features/Sensitivity to radiotherapy分类
医药卫生引用本文复制引用
侯跃,高宇,闫文明..核转录因子κB、多肿瘤抑制基因与宫颈癌临床特征及放疗敏感性的关系[J].川北医学院学报,2026,41(8):943-947,5.基金项目
吴阶平医学基金会科研专项资助基金(320.6750.2024-03-4) （320.6750.2024-03-4）
