川北医学院学报2026，Vol.41Issue(8)：948-952,5.DOI:10.3969/j.issn.1005-3697.2026.08.009
秋水仙碱联合尼可地尔治疗冠状动脉慢血流型心绞痛的短期疗效及作用机制
Short-term efficacy and mechanism of colchicine combined with nicorandil in patients with coronary slow flow-type angina
摘要
Abstract
Objective:To investigate the short-term efficacy and mechanism of colchicine combined with nicorandil in patients with coronary slow flow(CSF)-type angina.Methods:A total of 120 patients with CSF-type angina were selected and divided into an observation group(colchicine combined with nicorandil)and a control group(nicorandil alone)according to different treatment methods,with 60 cases in each group.After 12 weeks of treatment,the therapeutic effects,angina episodes,corrected Thrombolysis in Myocardial Infarction frame count(CTFC),endothelial function,inflammatory markers,oxidative stress indicators,and adverse reactions were compared between the two groups.Results:After 12 weeks of treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,the frequency and average duration of angina pectoris attacks,the corrected TIMI frame count(CTFC)of the left anterior descending artery(LAD),left circumflex artery(LCX),and right coronary artery(RCA),endothelin-1(ET-1),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),myeloperoxidase(MPO)and the MPO/paraoxonase(PON)ratio in both groups were lower than those of before treatment(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).The levels of nitric oxide(NO)and flow-mediated dilation(FMD)in both groups were higher than those of before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Colchicine combined with nicorandil improves the short-term efficacy in patients with CSF-type angina,and its mechanism may be related to synergistic effects such as improving vascular endothelial function,anti-inflammation,and reducing oxidative stress.关键词
秋水仙碱/尼可地尔/冠状动脉慢血流/心绞痛/短期疗效/作用机制Key words
Colchicine/Nicorandil/Coronary slow flow/Angina/Short-term efficacy/Mechanism分类
医药卫生引用本文复制引用
马洪皓,王延玲,王炳程,杨静..秋水仙碱联合尼可地尔治疗冠状动脉慢血流型心绞痛的短期疗效及作用机制[J].川北医学院学报,2026,41(8):948-952,5.基金项目
河北省中医药类科研计划项目(2022228) （2022228）
