川北医学院学报2026，Vol.41Issue(8)：953-956,4.DOI:10.3969/j.issn.1005-3697.2026.08.010
肝脏瞬时弹性成像在慢性乙型肝炎患者肝纤维化分级及抗病毒疗效评价中的应用
Application of transient elastography in assessing the degree of liver fibrosis and the efficacy of antiviral treatment in patients with chronic hepatitis B
摘要
Abstract
Objective:To analyze the value of transient elastography(TE)in assessing the degree of liver fibrosis and the efficacy of antiviral treatment in patients with chronic hepatitis B(CHB).Methods:A total of 186 patients with CHB who underwent TE to obtain liver stiffness measurement(LSM).According to liver biopsy results,patients were divided into the non-significant fibrosis group(F0-1),the significant fibrosis group(F2-3),and the cirrhosis group(F4).Patients with liver fibrosis≥F2 were given antiviral treatment and followed up for 12 months.Based on treatment response,they were further grouped.LSM values were compared among patients with different degrees of liver fibrosis and different treatment outcomes.The correlation between LSM and the degree of liver fibrosis,and the predictive efficacy for treatment effect were analyzed.Results:LSM increased with the progression of liver fibrosis(P<0.05).LSM was positively correlated with the degree of liver fibrosis(P<0.05).For the 111 patients who received antiviral treatment,the non-response group had higher LSM than the response group(P<0.05).The area under the curve of LSM in predicting the efficacy was 0.813,with sensitivity of 80.20%and specificity of 73.30%.Conclusion:TE demonstrates good value in assessing the degree of liver fibrosis and the efficacy of antiviral treatment in patients with CHB.关键词
慢性乙型肝炎/肝脏瞬时弹性成像/肝纤维化/抗病毒治疗/评估Key words
Chronic hepatitis B/Transient elastography/Liver fibrosis/Antiviral treatment/Assessment分类
医药卫生引用本文复制引用
杨雅兰,刘家开,周春美,何谦..肝脏瞬时弹性成像在慢性乙型肝炎患者肝纤维化分级及抗病毒疗效评价中的应用[J].川北医学院学报,2026,41(8):953-956,4.基金项目
四川省干部保健科研课题(川干研2021-201) （川干研2021-201）
