成都中医药大学学报2026，Vol.49Issue(4)：1-11,11.DOI:10.13593/j.cnki.51-1501/r.2026.04.001
人工智能虚拟细胞技术赋能中医药现代化研究
Artificial Intelligence Virtual Cell for the Modernization of Traditional Chinese Medicine
摘要
Abstract
Artificial Intelligence Virtual Cell(AIVC)is a multi-scale modeling approach that integrates multi-omics data with deep learning techniques,capable of simulating dynamic cellular behaviors at molecular,cellular,and tissue levels,and predicting cellular responses under stimuli such as genetic perturbations or drug interventions.The modernization of Traditional Chinese Medicine(TCM)still faces several major challenges,including unclear mechanisms underlying multi-component herbal formulations,low efficiency in active compound screening,and the limited dimensionality of conventional experimental approaches.These challenges highlight the ur-gent need for innovative research methodologies.By reviewing the technical principles and developmental trajectory of AIVC,this study explores its potential application pathways in TCM research.On this basis,an AIVC-based framework for mechanism elucidation and drug discovery in TCM.This framework encompasses five core stages,namely data integration,model construction,target screening,mechanism inference,and experimental validation.This framework aims to provide a new paradigm for elucidating the multi-target syn-ergistic mechanisms of herbal formulations and for identifying their active components.In addition,the major challenges currently faced in this field are discussed,and future development directions are outlined.AIVC is expected to promote the transformation of TCM re-search from an experience-driven paradigm to a data-driven paradigm,thereby providing essential technological support for the moderni-zation of TCM.关键词
人工智能虚拟细胞/中药复方/多组学数据融合/作用机制解析/药物发现Key words
Artificial intelligence virtual cell/Traditional Chinese medicine formulas/Multi-omics data fusion/Mechanism of action/Drug discovery分类
医药卫生引用本文复制引用
徐国庆,李嘉琪,陈伟..人工智能虚拟细胞技术赋能中医药现代化研究[J].成都中医药大学学报,2026,49(4):1-11,11.基金项目
四川省重大科技专项(2024ZDZX0019) （2024ZDZX0019）
