广东医学2026，Vol.47Issue(7)：984-990,7.DOI:10.13820/j.cnki.gdyx.20261284
肾小管酸中毒继发性骨质疏松症的诊疗新进展
Mechanisms,diagnosis,and treatment of renal tubular acidosis-associated secondary osteoporosis
摘要
Abstract
Renal tubular acidosis(RTA)is a clinical syndrome characterized by impaired renal acidification function,and the resulting chronic metabolic acidosis is an important risk factor for the development and progression of os-teoporosis.At present,the pathophysiological mechanisms underlying RTA-associated secondary osteoporosis have not been fully elucidated,and its clinical diagnostic and therapeutic strategies still require further optimization.This review systematically summarizes the pathophysiological mechanisms by which different types of RTA contribute to osteoporosis,including the complex effects of chronic metabolic acidosis on bone mineral homeostasis,osteoblast and osteoclast func-tion,and skeletal metabolism.The clinical characteristics of RTA-associated osteoporosis are also discussed.Further-more,this article reviews current therapeutic strategies targeting RTA itself,including alkali supplementation therapy,cor-rection of electrolyte disturbances,and the application of glucocorticoids and immunosuppressive agents,as well as their potential effects on osteoporosis.This review aims to provide an important theoretical basis and practical guidance for the clinical recognition and management of this special type of metabolic bone disease.关键词
肾小管酸中毒/骨质疏松/代谢性骨病/治疗Key words
renal tubular acidosis/osteoporosis/metabolic bone disease/treatment分类
医药卫生引用本文复制引用
唐存贵,李楠,吴海华,李佳..肾小管酸中毒继发性骨质疏松症的诊疗新进展[J].广东医学,2026,47(7):984-990,7.基金项目
国家重点研发计划(2021YFC2501701) （2021YFC2501701）
国家卫生健康委能力建设和继续教育中心2025年度慢病管理研究课题(GWJJMB202510024006) （GWJJMB202510024006）
