广东医学2026，Vol.47Issue(7)：998-1002,5.DOI:10.13820/j.cnki.gdyx.20261844
良性前列腺增生症与继发性骨质改变的相关性研究进展
Advances in the association between benign prostatic hyperplasia and secondary skeletal disorders
摘要
Abstract
Benign prostatic hyperplasia(BPH)is the most common urological disorder among middle-aged and older men.Emerging evidence indicates that patients with BPH frequently exhibit secondary skeletal abnormalities,inclu-ding reduced bone mineral density,osteoporosis,and even fragility fractures.These conditions are linked through multiple interconnected mechanisms,including sex hormone imbalance,chronic low-grade inflammation,metabolic dysregula-tion,and activation of the renin-angiotensin system.Based on recent advances in both basic and clinical research,this review systematically summarizes the epidemiological evidence,potential pathophysiological mechanisms,and clinical im-plications underlying the association between BPH and secondary skeletal disorders.It also highlights the importance of early screening,risk stratification,and individualized prevention and management of skeletal complications in patients with BPH,thereby providing insights for improving comprehensive care in this population.关键词
良性前列腺增生症/继发性骨质改变/骨质疏松/性激素/慢性炎症Key words
benign prostatic hyperplasia/secondary skeletal disorders/osteoporosis/sex hormones/chronic in-flammation分类
医药卫生引用本文复制引用
张磊,李佳..良性前列腺增生症与继发性骨质改变的相关性研究进展[J].广东医学,2026,47(7):998-1002,5.基金项目
国家重点研发计划(2021YFC2501701) （2021YFC2501701）
国家卫生健康委能力建设和继续教育中心2025年度慢病管理研究课题(GWJJMB202510024006) （GWJJMB202510024006）
