国际生殖健康/计划生育杂志2026，Vol.45Issue(4)：301-305,5.DOI:10.12280/gjszjk.20260109
生长激素/胰岛素样生长因子-1轴调控男性生殖功能的研究进展
Research Progress on the Growth Hormone/Insulin-Like Growth Factor-1 Axis in Regulating Male Reproductive Function
陈天泽 1王丹丹 1洪菊生 1杨光平1
作者信息
- 1. 225000 扬州大学附属扬州妇幼保健院生殖医学中心
- 折叠
摘要
Abstract
Growth hormone(GH)/insulin-like growth factor-1(IGF-1)axis not only participates in body growth and development as well as energy homeostasis maintenance,but also plays a significant role in the regulation of male reproductive function.At the central level,IGF-1 can participate in the regulation of gonadotropin-releasing hormone and luteinizing hormone secretion through influencing the excitability of hypothalamic Kisspeptin/neurokinin B/dynorphin(KNDy)neurons.At the testicular level,the GH/IGF-1 axis can affect testosterone synthesis and spermatogenesis by regulating the functions of Leydig cells and Sertoli cells,enhancing the responsiveness of testis to gonadotropin,and improving the local microenvironment of spermatogenesis.At the peripheral effect level,GH/IGF-1 axis may participate in the regulation of erectile function by maintaining endothelial cell function,regulating the nitric oxide/cyclic guanosine monophosphate(NO/cGMP)signal pathway,supporting nerve repair and maintaining the stability of the smooth muscle of the corpus cavernosum.However,the existing evidence is mainly based on animal experiments,in vitro studies and small-sample clinical observations,and the impact of the GH/IGF-1 axis on male reproductive functions is not a one-way promotion.There is still a lack of high-quality clinical intervention studies to support its routine application.关键词
生长激素/胰岛素样生长因子Ⅰ/不育,男(雄)性/垂体激素类/勃起功能障碍Key words
Growth hormone/Insulin-like growth factor Ⅰ/Infertility,male/Pituitary hormones/Erectile dysfunction引用本文复制引用
陈天泽,王丹丹,洪菊生,杨光平..生长激素/胰岛素样生长因子-1轴调控男性生殖功能的研究进展[J].国际生殖健康/计划生育杂志,2026,45(4):301-305,5.
