国际生殖健康/计划生育杂志2026，Vol.45Issue(4)：306-310,5.DOI:10.12280/gjszjk.20260238
心理应激致生殖功能障碍的动物模型及机制研究进展
Research Progress on the Animal Models and Mechanisms of Psychological Stress-Induced Reproductive Dysfunction
摘要
Abstract
Psychological stress disrupts reproductive function through a multi-system network,which is a research focus in reproductive medicine.Common methods for modeling chronic psychological stress include chronic restraint stress,chronic unpredictable mild stress,social defeat stress,social isolation stress,and early-life stress.Psychological stress activates the hypothalamic-pituitary-adrenal(HPA)axis while inhibiting the hypothalamic-pituitary-gonadal(HPG)axis,leading to abnormal sex hormone secretion.It also induces oxidative damage and chronic inflammatory responses in reproductive tissues.Gut microbiota dysbiosis further amplifies the stress effect through the gut-brain-gonad axis,and epigenetic modifications mediate the long-term persistence and transgenerational transmission of stress effects.Future efforts should integrate multi-omics technologies to construct the standardized animal models of chronic stress,and to explore early intervention targets and personalized treatment strategies for stress-related reproductive dysfunction,thereby providing a theoretical foundation for clinical prevention and treatment.关键词
应激,心理学/疾病模型,动物/生殖/不育/神经内分泌学/后成说,遗传Key words
Stress,psychological/Disease models,animal/Reproduction/Infertility/Neuroendocrinology/Epigenesis,genetic引用本文复制引用
刘金玉,马瑞红,赵志梅..心理应激致生殖功能障碍的动物模型及机制研究进展[J].国际生殖健康/计划生育杂志,2026,45(4):306-310,5.基金项目
国家自然科学基金(82374508) （82374508）
