河北工业科技2026，Vol.43Issue(4)：300-309,10.DOI:10.7535/hbgykj.2026yx04002
AHP-EWM结合响应面法优化小儿祛湿止痒颗粒提取工艺
Optimization of extraction process of Xiao'er Qushi Zhiyang Granules based on AHP-EWM combined with response surface methodology
摘要
Abstract
To improve the extraction yield of effective components from Xiao'er Qushi Zhiyang Granules and enhance the stability of preparation quality,this study optimizes the water extraction process of Xiao'er Qushi Zhiyang Granules by combining single-factor experiments with the Box-Behnken response surface methodology.The amount of added water,extraction time and soaking time were selected as investigation factors,while the contents of rosmarinic acid,paeoniflorin and obacunone and the yield of dry extract were adopted as evaluation indicators.A combined weighting method of Analytic Hierarchy Process-Entropy Weight Method(AHP-EWM)was applied to calculate the comprehensive score.Response surface methodology was employed to analyze the interaction between factors,optimize process parameters,and carry out methodological research and process validation.The results show that the optimal water extraction process is as follows:adding eight times the amount of water,soaking for 30 minutes,extracting two times,with a total extraction time of three hours.Under this process,the comprehensive score is 95.80 with RSD=0.96%,and the relative error compared with the predicted value is less than 1.0%.In conclusion,this process is stable,feasible and has good reproducibility,which can sufficiently extract paeoniflorin,rosmarinic acid,obacunone and other core pharmacodynamically active components in the formula,and can provide a reference for the industrial production and quality control of Xiao'er Qushi Zhiyang Granules.关键词
中药药剂/小儿祛湿止痒颗粒/响应面法/Box-Behnken设计/AHP-EWM/水提取工艺/提取工艺优化Key words
traditional Chinese medicine preparations/Xiao'er Qushi Zhiyang Granules/response surface method/Box-Behnken design/AHP-EWM/water extraction process/optimization of extraction process分类
医药卫生引用本文复制引用
陈俊梅,王仪然,王医瞻,刘彦芬,王仪凡,徐林平..AHP-EWM结合响应面法优化小儿祛湿止痒颗粒提取工艺[J].河北工业科技,2026,43(4):300-309,10.基金项目
河北省中医药管理局科研计划项目(2023ZY017) （2023ZY017）
石家庄市卫生健康委医学科学研究课题(2023YZ006) （2023YZ006）
