郑州大学学报（医学版）2026，Vol.61Issue(4)：17-21,5.DOI:10.13705/j.issn.1671-6825.2025.08.034
常见7种矿物质与2型糖尿病因果关联的孟德尔随机化研究
Mendelian randomization study on the causal associations between 7 com-mon minerals and type 2 diabetes mellitus
摘要
Abstract
Aim:To investigate the causal associations between 7 common minerals(copper,selenium,zinc,calcium,i-ron,magnesium,and potassium)and the risk of type 2 diabetes mellitus(T2DM).Methods:Based on genome-wide associ-ation study databases,forward Mendelian randomization(MR)analysis was conducted using SNPs related with blood con-centration of 7 minerals as exposures and T2DM-related SNPs as the outcome;reverse MR analysis was performed with T2DM-related SNPs as exposures and the 7 minerals' SNPs as outcomes.MR analysis was conducted using SNPs of 7 miner-als as exposures and T2DM-related characteristics,including glycated hemoglobin,fasting insulin,fasting blood glucose,HO-MA-IR,HOMA-β,and insulin receptor,as outcomes.Inverse variance weighting(IVW)method was employed as the prima-ry analytical approach,supplemented by 4 additional methods(MR-Egger,weighted median,simple pattern,and weighted pattern).Heterogeneity was assessed using Cochran's Q test,heterogeneity was evaluated with the MR-Egger intercept test,and sensitivity analyses were conducted via the leave-one-out method.Results:Forward MR analysis using the IVW method revealed that selenium may increase the risk of T2DM(OR was 1.036,95%CI was 1.002 to 1.071),whereas reverse MR analysis with IVW showed no association between T2DM and selenium(OR was 1.087,95%CI was 0.971 to 1.217),and the supplementary methods yielded consistent results with the IVW approach,demonstrating robust predictive validity.No associations were found between other minerals and T2DM(P>0.05).Selenium exhibited causal relationships with fasting blood glucose(OR was 1.025,95%CI was 1.008 to 1.042)and insulin resistance index(OR was 1.033,95%CI was 1.011 to 1.057).Conclusion:Higher selenium levels are associated with an increased risk of T2DM.关键词
矿物质/2型糖尿病/孟德尔随机化/因果关联Key words
mineral/type 2 diabetes mellitus/Mendelian randomization/causal association分类
医药卫生引用本文复制引用
马海莲,赵玉涵,吴乃君,吴磊,侯丽颖,李爽,张溪桐..常见7种矿物质与2型糖尿病因果关联的孟德尔随机化研究[J].郑州大学学报（医学版）,2026,61(4):17-21,5.基金项目
河北省自然科学基金项目(H2024209070) （H2024209070）
河北省医学科学研究课题计划(20251012) （20251012）
华北理工大学高校基本科研业务项目(JQN2023039,JQN2023042) （JQN2023039,JQN2023042）
