郑州大学学报（医学版）2026，Vol.61Issue(4)：22-26,5.DOI:10.13705/j.issn.1671-6825.2025.07.074
肠道菌群与阿尔茨海默病双向因果关联的孟德尔随机化法分析
Bidirectional causal association between gut microbiota and Alzheimer's disease based on Mendelian randomization
摘要
Abstract
Aim:To investigate the potential causal relationship between gut microbiota(GM)and Alzheimer's disease(AD).Methods:Genome-wide association study(GWAS)data of 473 GM variants,as well as GWAS of AD from the Finn-ish R12 database were collected.Using single nucleotide polymorphisms(SNPs)of these 473 GM variants as exposures and AD as the outcome variable,forward Mendelian randomization(MR)analysis was conducted;using AD-associated SNPs as exposures and the microbial communities identified by forward MR analysis as the outcome variable,reverse MR analysis was performed.Results:The results of the inverse variance weighting(IVW)method for forward MR indicated that cya-nobacteria,and Francisellales Firmicutes-CAG-110[OR(95%CI)was 1.241(1.006-1.531)],[1.115(1.003-1.240)],[1.594(1.121-2.266)],Lachnospiraceae-CAD-488,Eubacterium,Klebsiella,Azorhizobium,Pseudocatenibacte-rium sp,GCA-900066135,sp900066135 were positively correlated with AD.There was a negative correlation between AD and sp002160815 species in the order arechlamydiales[OR(95%CI)was 0.586(0.356-0.967)],sporangiales[0.652(0.428-0.993)],family Trichomycteridae-CAG-449,family Desulfovibrio,genus Spirosporium,and genus Maasai.Re-verse MR analysis revealed no reverse causal relationship between the aforementioned 15 GM species and AD.Conclusion:Partial GM may be causal associated with AD.关键词
肠道菌群/阿尔茨海默病/孟德尔随机化Key words
gut microbiota/Alzheimer's disease/Mendelian randomization分类
医药卫生引用本文复制引用
李德臣,李彦杰..肠道菌群与阿尔茨海默病双向因果关联的孟德尔随机化法分析[J].郑州大学学报（医学版）,2026,61(4):22-26,5.基金项目
河南省自然科学基金项目(242300420111) （242300420111）
河南省研究生教育改革与质量提升工程项目(精品教材项目)中医康复研究进展(YJS2024JC26) （精品教材项目）
