河南中医2026，Vol.46Issue(8)：1163-1168,6.DOI:10.16367/j.issn.1003-5028.2026.08.0189
黄连阿胶汤治疗脑卒中后失眠疗效观察
Efficacy Observation of Coptis and Donkey-Hide Gelatin Decoction in the Treatment of Post-Stroke Insomnia
摘要
Abstract
Objective:To observe the clinical efficacy of Coptis and Donkey-Hide Gelatin Decoction in the treatment of post-stroke insom-nia(PSI)and its effects on gamma-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),and the glutamic acid(Glu)/GABA ra-tio in patients.Methods:A total of 120 PSI patients were randomly divided into the treatment group and the control group using the ran-dom number table method,with 60 cases in each group.The control group received conventional Western medicine,while the treatment group received Coptis and Donkey-Hide Gelatin Decoction in addition to the conventional Western medicine.Then clinical efficacy,inci-dence of adverse reactions,and changes in sleep quality[Pittsburgh sleep quality index(PSQI)score,insomnia severity index(ISI)score],polysomnography parameters[rapid eye movement percentage(REM％),non-rapid eye movement stage 3 percentage(N3％),wake after sleep onset(WASO)],and neurotransmitter levels(GABA,5-HT,Glu/GABA ratio)before and after treatment were com-pared between the two groups.Results:The effective rate was 78.33％in the control group and 93.33％in the treatment group,with a statistically significant difference between the two groups(P<0.05).After treatment,PSQI and ISI scores in both groups were lower than those before treatment,and the scores in the treatment group were lower than those in the control group,with statistically significant differences(P<0.05).REM％and N3％increased,while WASO decreased in both groups compared with baseline,with statistically significant differences between the two groups(P<0.05).GABA and 5-HT levels increased,and the Glu/GABA ratio decreased in both groups compared with baseline,with statistically significant differences between the two groups(P<0.05).However,no significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Coptis and Donkey-Hide Gelatin Decoction can improve sleep quality and optimize objective sleep architecture in patients with PSI.Its mechanism may be associ-ated with the regulation of neurotransmitters such as GABA,5-HT,and the Glu/GABA ratio.关键词
脑卒中后失眠/黄连阿胶汤/艾司唑仑片/中西医结合疗法/《伤寒论》/张仲景Key words
post-stroke insomnia(PSI)/Coptis and Donkey-Hide Gelatin Decoction/Estazolam Tablets/integrated traditional Chinese and Western medicine therapy/Treatise on Cold Damage Diseases/Zhang Zhongjing分类
医药卫生引用本文复制引用
卢雁冰,朱梦婷,董文征..黄连阿胶汤治疗脑卒中后失眠疗效观察[J].河南中医,2026,46(8):1163-1168,6.基金项目
河南省医学科技攻关计划项目(LHGJ20240998) （LHGJ20240998）
