四川大学学报（医学版）2026，Vol.57Issue(4)：925-932,8.DOI:10.12182/20260760201
中医"治未病"指导口腔-全身抗衰老机制与干预策略
Oral-Systemic Antiaging Mechanisms and Intervention Strategies Guided by Traditional Chinese Medicine Principle of Preventive Treatment of Disease
摘要
Abstract
Population aging has become a global issue,and aging-related diseases have emerged as a major public health challenge.Inflammatory aging—the fundamental pathological basis of aging-related diseases—is closely associated with oral health status.However,current research and clinical practice remain limited by bottleneck issues,such as the separation of oral and systemic prevention and treatment strategies and the lack of systematic approaches to break the oral-systemic vicious cycle.This review addresses both the mechanisms and intervention strategies of the bidirectional oral-systemic regulation in anti-aging.We propose that the oral cavity serves as a precursory warning window for systemic aging and provide an in-depth analysis of the underlying mechanisms by which the oral cavity and the whole body form a bidirectional vicious pathogenic cycle through the immune-inflammatory network.At the molecular level,3 key pathways are highlighted,including the lipopolysaccharide(LPS)/Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)axis,the advanced glycation end products(AGEs)/receptor for advanced glycation end products(RAGE)axis,and the oral-brain neural feedback pathway.On this basis and under the guidance of the traditional Chinese medicine(TCM)principle of preventive treatment of disease,a three-tier collaborative intervention system covering the entire life course is proposed.Supported by multidisciplinary collaboration,a new integrated model incorporating early warning,intervention,and rehabilitation is established,thereby providing a comprehensive solution that integrates the holistic approach of TCM with modern life sciences to address the challenges of population aging.关键词
治未病/抗衰老/口腔-全身/慢性炎症/中西医协同干预/综述Key words
Preventive treatment of disease/Antiaging/Oral-systemic/Chronic inflammation/Integrated traditional Chinese and Western medicine intervention/Review引用本文复制引用
艾黄萍,李春财,金钊,左渝陵..中医"治未病"指导口腔-全身抗衰老机制与干预策略[J].四川大学学报（医学版）,2026,57(4):925-932,8.基金项目
This study was supported by the Sichuan Provincial Natural Science Foundation(No.2026NSFSC0492). 四川省自然科学基金(No.2026NSFSC0492)资助 （No.2026NSFSC0492）
