四川大学学报（医学版）2026，Vol.57Issue(4)：953-958,6.DOI:10.12182/20260760602
口腔微生态在衰老相关稳态失衡及系统性疾病中的作用研究进展
Research Advances on the Role of the Oral Microbiota in Age-Related Homeostatic Dysregulation and Systemic Diseases
摘要
Abstract
The regulatory role of the microbiota in the aging process has increasingly attracted attention.As a crucial microbial ecosystem of the human body,the oral microbiota plays a unique role in maintaining host health and contributing to disease development.This review summarizes the dynamic changes in specific oral microbial genera under both healthy and diseased conditions,analyzes the impact of age-related physiological alterations of the oral cavity on the microbiota,and comprehensively elucidates the mechanisms by which age-associated oral microbial dysbiosis participates in oral and systemic diseases.Given the close interplay between the oral microbiota and aging,its significance in promoting healthy aging has become increasingly prominent.Investigating the succession patterns of the oral microbiota not only helps to unravel the mechanisms underlying the high incidence of systemic diseases in the elderly,but also provides a theoretical basis for developing microbiota-based intervention strategies and identifying novel early-biomarkers for healthy aging.关键词
衰老/口腔/生态失调/疾病/健康老龄化/综述Key words
Aging/Oral cavity/Dysbiosis/Disease/Healthy aging/Review引用本文复制引用
何卓家,李栋梁,彭显..口腔微生态在衰老相关稳态失衡及系统性疾病中的作用研究进展[J].四川大学学报（医学版）,2026,57(4):953-958,6.基金项目
This study was supported by the National Natural Science Foundation of China(No.32470108). 国家自然科学基金(No.32470108)资助 （No.32470108）
