杭州师范大学学报（自然科学版）2026，Vol.25Issue(4)：385-391,428,8.DOI:10.19926/j.cnki.issn.1674-232X.2025.03.251
新生期缺氧对小鼠肠道的损伤作用及机制研究
Effects and mechanisms of neonatal hypoxia-induced intestinal injury in mice
摘要
Abstract
To reveal the pathological basis of neonatal hypoxic enteropathy,this study used newborn mice as a model to investigate the damaging effects of hypoxia on intestinal tissue during the neonatal period and the underlying mechanisms from both morphological and molecular perspectives.The results showed that hypoxia led to a significant decrease in body weight of neonatal mice.Hematoxylin and eosin(HE)staining results indicated that hypoxia caused developmental abnormalities in the ileum and distal colon of mice,manifested as necrosis of intestinal epithelial cells,inflammatory cell infiltration,and damage to the mucosal barrier.The Stress&Toxicity Pathway Finder PCR revealed that hypoxia broadly perturbed multiple key molecular pathways.The expression of the oxidative stress-related gene Sod1 was downregulated,while the expression of Ldha(involved in energy metabolism reprogramming),the water channel protein Aqp4,the key pyroptosis molecule Caspase-1,the necroptosis molecule Ripk3,and the inflammatory signaling molecules Ccl12,Mmp9,and Tlr4 were all significantly upregulated.Additionally,the expression of the autophagy-related gene Atg7 was inhibited.These findings suggest that neonatal hypoxia may mediate intestinal structural and functional damage through multiple mechanisms,including oxidative stress imbalance,energy metabolism dysregulation,programmed cell death,inflammatory responses,and autophagy inhibition.关键词
新生期缺氧/肠道损伤/氧化应激Key words
neonatal hypoxia/intestinal injury/oxidative stress分类
生物科学引用本文复制引用
吴越,张烽锋,王燕楚,温俊,赵晓枫,陶华平..新生期缺氧对小鼠肠道的损伤作用及机制研究[J].杭州师范大学学报（自然科学版）,2026,25(4):385-391,428,8.基金项目
国家自然科学基金项目(32471022) （32471022）
杭州师范大学2024-2025学年"本科生创新能力提升工程"项目 （）
