杭州师范大学学报（自然科学版）2026，Vol.25Issue(4)：401-407,7.DOI:10.19926/j.cnki.issn.1674-232X.2025.06.032
紫杉醇-薏苡仁油-β-榄香烯脂质微乳复合递药系统的制备及体外释药研究
Preparation and in vitro drug release investigation of paclitaxel-coix seed oil-β-elemene lipid microemulsion composite drug delivery system
摘要
Abstract
Based on the previously successfully prepared paclitaxel-coix seed oil microemulsion,it was further encapsulated into the β-elemene lipid layer to construct a paclitaxel-coix seed oil-β-elemene lipid microemulsion composite drug delivery system,which was systematically characterized and its drug content was determined.Dynamic light scattering(DLS)results showed that the particle size of the composite system was(128.10±2.86)nm,and the Zeta potential was(-15.07±1.03)mV.Transmission electron microscopy(TEM)observation revealed that the microemulsion was successfully encapsulated within the liposomes,forming a"larger sphere encapsulating small sphere"structure.High performance liquid chromatography(HPLC)showed that the encapsulation efficiencies of paclitaxel and β-elemene were(99.40±0.51)％and(76.55±0.61)％,respectively,and the drug loading capacities were(0.90±0.01)％and(3.65±0.02)％,respectively.In vitro drug release experiments showed that β-elemene exhibited preferential release compared with paclitaxel,which may help ameliorate in the drug-resistant microenvironment before the massive release of paclitaxel.关键词
紫杉醇/β-榄香烯/微乳/脂质体Key words
paclitaxel/β-elemene/microemulsion/liposome分类
医药卫生引用本文复制引用
熊锐,曹雨庆,张紫薇,潘青松,钱智磊,陈云艳..紫杉醇-薏苡仁油-β-榄香烯脂质微乳复合递药系统的制备及体外释药研究[J].杭州师范大学学报（自然科学版）,2026,25(4):401-407,7.基金项目
国家自然科学基金项目(82404747) （82404747）
安徽省自然科学基金项目(2108085QH370) （2108085QH370）
安徽省优秀青年教师培育项目(YQYB2024046) （YQYB2024046）
皖南医学院校重点科研基金项目(WK2024ZZD11) （WK2024ZZD11）
安徽省教育厅自然科学研究项目(2025AHGXZK30634) （2025AHGXZK30634）
