江苏大学学报（医学版）2026，Vol.36Issue(4)：347-351,5.DOI:10.13312/j.issn.1671-7783.y250184
艾普拉唑和氯吡格雷在人体内的药代动力学相互作用
Pharmacokinetic interaction between ilaprazole and clopidogrel in humans
摘要
Abstract
Objective:To evaluate the effect of steady-state ilaprazole on the pharmacokinetics of clopidogrel in healthy subjects.Methods:A randomized,open-label,crossover,self-controlled trial was conducted.A total of 40 healthy subjects were randomly assigned to two groups(Group A and Group B,n=20 each).Group A received clopidogrel 75 mg once daily for 7 consecutive days;Group B received clopidogrel 75 mg plus ilaprazole 10 mg once daily for 7 days.After a 10-day washout period,the two groups crossed over to the alternative regimen.Plasma concentrations of clopidogrel,its active metabolite,and clopidogrel carboxylic acid were determined for pharmacokinetic analysis.Results:The 90％CI of the geometric mean ratios for systemic exposure of clopidogrel active metabolite in the all subjects and CYP2C19 extensive metabolizers were within the range of 0.80 to 1.25.Conclusion:No clinically significant pharmacokinetic interaction was observed between ilaprazole and clopidogrel in healthy subjects,nor was there obvious clinical relevance in CYP2C19 extensive metabolizers.关键词
氯吡格雷/艾普拉唑/药物相互作用/药代动力学/质子泵抑制剂/CYP2C19/活性代谢物Key words
clopidogrel/ilaprazole/drug-drug interaction/pharmacokinetics/proton pump inhibitor/CYP2C19/active metabolite分类
医药卫生引用本文复制引用
盛宇辰,周素凤,谢利军,周辰,王洪允,邵凤..艾普拉唑和氯吡格雷在人体内的药代动力学相互作用[J].江苏大学学报（医学版）,2026,36(4):347-351,5.基金项目
国家十三五重大新药创制专项(2018ZX09734-007) （2018ZX09734-007）
