江西中医药大学学报2026，Vol.38Issue(4)：35-42,8.DOI:10.20140/j.2095-7785.2026.04.10
消瘤治萎方治疗慢性萎缩性胃炎的疗效回顾性分析与网络药理学机制初探
Retrospective Analysis of the Efficacy of Xiaoliu Zhiwei Formula in Treating Chronic Atrophic Gastritis and Preliminary Exploration of its Mechanism via Network Pharmacology
摘要
Abstract
Objective:To retrospectively summarize and analyze the clinical efficacy of Xiaoliu Zhiwei Formula(XLZWF)in treating chronic atrophic gastritis(CAG)and to preliminarily explore its mechanism of action.Methods:Clinical data of CAG patients from the Department of Spleen,Stomach,Liver,and Gallbladder of the Affiliated Hospital of Jiangxi University of Chinese Medicine between December 2022 and December 2024 were collected.Patients were divided into an experimental group(XLZWF)and a control group(conventional western medicine)based on different treatment methods.The gastroscope,pathology(atrophy,intestinal metaplasia,intraepithelial neoplasia),traditional Chinese medicine(TCM)syndrome score,and clinical efficacy were analyzed in both groups.Network pharmacology,bioinformatics,and molecular docking techniques were also used for preliminary exploration of its mechanism.Results:The retrospective analysis showed that after treatment,the gastroscope score,pathology score,and syndrome score in the experimental group were significantly better than those in the control group(all P<0.01).Additionally,various observation indicators improved in both groups compared to before treatment(P<0.05 or P<0.01).The total effective rates for gastroscope efficacy,pathological efficacy,syndrome efficacy,and clinical efficacy in the experimental group were 71.20%,80.30%,83.33%,and 66.67%,respectively,which were significantly higher than those in the control group(all P<0.01).Through network pharmacology analysis,118 common targets between inflammation-to-cancer transformation of CAG and XLZWF were identified.GO and KEGG enrichment analysis showed that targets were enriched in the PI3K-PKB/Akt,IL-17,FoxO,TNF,and p53 signaling pathways,and Cytoscape-related modules further identified 22 core genes.Molecular docking showed interactions between quercetin and potential core genes.Conclusion:This study preliminarily confirmed that XLZWF is superior to traditional western medicine in CAG patients.Network pharmacology analysis suggests that XLZWF may treat CAG by regulating the PI3K-PKB/Akt,IL-17,FoxO,TNF,and p53 signaling pathways,and these findings require further experimental verification.关键词
慢性萎缩性胃炎/消瘤治萎方/槲皮素/回顾性分析/网络药理学/生物信息学/分子对接技术Key words
Chronic Atrophic Gastritis/Xiaoliu Zhiwei Formula/Quercetin/Retrospective Study/Network Pharmacology/Bioinformatics/Molecular Docking Technology分类
医药卫生引用本文复制引用
陈梦琳,涂厚姝,习志伟,何凌..消瘤治萎方治疗慢性萎缩性胃炎的疗效回顾性分析与网络药理学机制初探[J].江西中医药大学学报,2026,38(4):35-42,8.基金项目
第五批全国优秀中医临床优秀人才研修项目(国中医药人教函[2022]1号) （国中医药人教函[2022]1号）
国家中医优势专科建设项目(赣财社指[2024]39号). （赣财社指[2024]39号）
