检验医学与临床2026，Vol.23Issue(15)：2030-2035,2042,7.DOI:10.3969/j.issn.1672-9455.2026.15.003
盐酸二甲双胍联合利格列汀治疗对肥胖型T2DM患者胰岛素抵抗及血清vaspin水平的影响
Effect of metformin hydrochloride combined with linagliptin therapy on insulin resistance and serum vaspin level in obese patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the effects of metformin hydrochloride combined with linagliptin ther-apy on insulin resistance and serum serine protease inhibitor(vaspin)level in obese patients with type 2 diabe-tes mellitus(T2DM).Methods A total of 122 obese patients with T2DM admitted to Baoji Hospital Affilia-ted to Xi'an Medical University from February 2021 to January 2024 were enrolled as research subjects,and they were divided into a control group and an experimental group by the random number table method.All pa-tients received metformin hydrochloride treatment.On this basis,the control group was given placebo,while the experimental group was given linagliptin.The incidence of adverse reactions,blood glucose metabolism in-dexes[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 h PBG),glycated hemoglobin A1c(HbA1c)],body mass index(BMI),blood lipid indexes[triglyceride(TG),total cholesterol(TC),high-den-sity lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],islet cell function indexes[fasting insulin(FINS),homeostasis model assessment of β-cell function(HOMA-β),homeostasis model as-sessment of insulin resistance(HOMA-IR)]and serum vaspin levels were compared between the two groups before and after treatment.Results After treatment,the levels of FPG,2 h PBG,HbA1c,TC,TG and LDL-C in the two groups were lower than those before treatment,and the levels of FPG,2 h PBG,HbA1c,TC,TG and LDL-C in the experimental group were lower than those in the control group,the differences were statisti-cally significant(P<0.05).After treatment,the FINS level,HOMA-IR and BMI of the two groups were low-er than those before treatment,and the FINS level,HOMA-IR and BMI of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the HOMA-β and HDL-C levels of the two groups were higher than those before treatment,and the HOMA-β and HDL-C levels of the experimental group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the serum vaspin levels of the two groups were low-er than those before treatment,and the serum vaspin level of the experimental group was lower than that of the control group,and the differences were statistically significant(P<0.05).There was no significant differ-ence in the total incidence of adverse reactions between the two groups(P=0.697).Conclusion Metformin hydrochloride combined with linagliptin in the treatment of obese T2DM patients can reduce the blood glucose and blood lipid levels,improve insulin resistance,promote the recovery of islet cell function and reduce the ser-um vaspin level,with good safety.关键词
利格列汀/2型糖尿病/胰岛素抵抗/丝氨酸蛋白酶抑制剂/肥胖症/脂肪因子Key words
linagliptin/type 2 diabetes mellitus/insulin resistance/serine protease inhibitor/obe-sity/adipokine分类
医药卫生引用本文复制引用
廖静,刘建军,林春发..盐酸二甲双胍联合利格列汀治疗对肥胖型T2DM患者胰岛素抵抗及血清vaspin水平的影响[J].检验医学与临床,2026,23(15):2030-2035,2042,7.基金项目
陕西省重点研发计划项目(2022SF-227). （2022SF-227）
