兰州大学学报（医学版）2026，Vol.52Issue(5)：15-22,34,9.DOI:10.13885/j.issn.2097-681X.M20251673
亚临床甲减转归纵向随访及影响因素分析
A follow-up analysis of the outcome and influencing factors of subclinical hypothyroidism
摘要
Abstract
Objective To analyze the changes in thyroid function and their influencing factors among resi-dents in Lanzhou after a 10-year follow-up.Methods A total of 984 volunteers from Xigu District,Lanzhou,who participated in the National Epidemiological Survey of Thyroid Disorders,lodine Nutrition,and Diabetes in 2014,were included in this follow-up study.General information,biochemical indicators,and thyroid function measurements were collected and analyzed to examine the dynamic trends in thyroid function and identify factors influencing its progression.Results During the 10-year follow-up period,among individuals with a normal baseline thyroid function,54(8.82％)progressed to subclinical hypothyroidism(SCH).Of those with a baseline SCH,57(37.01％)returned to normal thyroid function,while 94(61.04％)remained in the SCH state.In the group that progressed from normal thyroid function to SCH,being female,elevated 2-hour postprandial glucose,and elevated thyroid-stimulating hormone levels were identified as risk factors for disease progression.Conclusion Thyroid function in SCH patients may spontaneously normalize to some extent during follow-up.Enhancing the understanding of the natural history of SCH and the factors contribut-ing to its normalization may aid in the development of clinical follow-up strategies in the future.关键词
亚临床甲减/促甲状腺激素/转归/影响因素/随访研究/兰州市Key words
subclinical hypothyroidism/thyroid stimulating hormone/outcome/influencing factor/follow-up study/Lanzhou city分类
医药卫生引用本文复制引用
赵彩芳,王佳蕾,路翔,滕卫平,单忠艳,傅松波..亚临床甲减转归纵向随访及影响因素分析[J].兰州大学学报（医学版）,2026,52(5):15-22,34,9.基金项目
国家重点研发计划资助项目(2023YFC3503400) （2023YFC3503400）
甘肃省内分泌疾病临床医学研究中心建设规划资助项目(20JR10FA667) （20JR10FA667）
甘肃省自然科学基金资助项目(22JR5RA914) （22JR5RA914）
甘肃省联合科研基金资助项目(23JRRA1490) （23JRRA1490）
兰州市科技发展指导性计划资助项目(2019-ZD-38) （2019-ZD-38）
"十四五"项目立项课题(2023YF2508305) （2023YF2508305）
