兰州大学学报（医学版）2026，Vol.52Issue(5)：48-54,7.DOI:10.13885/j.issn.2097-681X.M20250637
血栓标志物与缺血性脑卒中短期预后关系及预测模型研究
The relationship between thrombotic markers and the prognosis of ischemic stroke and establishment of a prognostic model
摘要
Abstract
Objective To analyze the relationship between the levels of thrombotic markers and the short-term prognosis of ischemic stroke,select laboratory test indicators related to poor prognosis of ischemic stroke,and construct a laboratory indicator model.Methods We tested 433 ischemic stroke patients for four thrombotic markers including plasma thrombomodulin(TM),thrombin anti-thrombin complex(TAT),plasmin-α2 anti-plasmin complex(PIC),tissue type plasminogen activator inhibitor-1 complex(t-PAI-C)upon initial admis-sion,and recorded their biological data,coagulation and fibrinolysis indicators,and other laboratory test results.We performed a short-term follow-up for 3 months,divided patients into two groups:a good prognosis group(MRS≤2)and poor prognosis group(MRS>2)based on the 90 days modified Rankin scale(MRS).We selected related indicators and constructed a laboratory prediction model for poor prognosis in patients with ischemic stroke.Results The levels of plasma TM[(9.83±3.14)vs(8.29±2.30)TU·mL-1],TAT[(3.70±3.48)vs(1.39±0.77)ng·mL-1],PIC[(0.70±0.56)vs(0.48±0.17)μg·mL-1],and t-PAI-C[(8.10±3.07)vs(6.14±2.71)ng·mL-1]in ischemic stroke patients were significantly higher than those in healthy controls(P<0.05).Univariate Logistic analysis showed that the plasma TAT,PIC,t-PAI-C,prothrombin time(PT),fibrinogen,D-Dimer and fibrin degradation product levels in the poor prognosis group were significantly higher than in the good prognosis group(P<0.05),while activated partial thromboplastin time levels in the former were sig-nificantly lower than in the latter(P<0.05).There were no significantly differences in TM,TT and antithrom-bin Ⅲ(P>0.05).In addition,the levels of glucose,monoamine oxidase,iron,triglycerides,C-reactive protein(CRP),troponin(TnT),lymphocyte count and free fatty acids(NEFA)were significant different between the two groups.Thus a prognostic evaluation model was established based on TAT,PIC,PT,CRP,TnT,and NEFA.Conclusions The levels of thrombotic markers in ischemic stroke patients are correlated with their short-term prognosis,and the model established using laboratory indicators TAT,PIC,PT,CRP,TnT,and NE-FA can be used to predict poor prognosis in ischemic stroke.关键词
缺血性脑卒中/血栓标志物/凝血纤溶标志物/实验室指标/预后模型Key words
ischemic stroke/thrombotic marker/coagulation and fibrinolysis marker/laboratory indicator/prognostic model分类
医药卫生引用本文复制引用
郜莉娜,杨雪妹,王向丽,宋佩佩,谢建琴,刘俊枫,尤崇革..血栓标志物与缺血性脑卒中短期预后关系及预测模型研究[J].兰州大学学报（医学版）,2026,52(5):48-54,7.基金项目
甘肃省联合科研基金资助项目(25JRRA1276) （25JRRA1276）
兰州市科技计划基金资助项目(2023-4-41) （2023-4-41）
兰州大学第二医院(第二临床医学院)萃英科技创新计划基金资助项目(CY2024-MS-A06) （第二临床医学院）
兰州大学第二医院(第二临床医学院)萃英学子科研培育计划基金资助项目(CYXZ2021-62,CYXZ2024-35) （第二临床医学院）
