兰州大学学报（医学版）2026，Vol.52Issue(5)：55-61,7.DOI:10.13885/j.issn.2097-681X.M20250689
基于外周血铁代谢相关指标的铁死亡积分和HGI对AIS预后评估价值分析
Analysis of the prognostic value of ferroptosis score and HGI based on peripheral blood iron metabolism related indexes for AIS
摘要
Abstract
Objective To explore the prognostic value of ferroptosis score and hemoglobin glycation index(HGI)established by peripheral blood iron metabolism related indicators in acute ischemic stroke(AIS).Methods In this study,190 AIS patients who were treated in Xi'an No.3 Hospital from January 2022 to December 2024 were included.Fasting venous blood was collected at admission to measure fasting blood glucose and glycosylated hemoglobin,and HGI was calculated.Enzyme-linked immunosorbent assay was used to detect neuronal filament light chain(NfL),4-hydroxy-2-nonenal(4-HNE),8-hydroxy-2'-deoxy-guanosine(8-oxo-dG),hepcidin,transferrin receptor(TfR),and ferritin.Prognosis at 90 days was evaluated using the modified Rankin scale(MRs),and patients were grouped into good(MRs≤2)or poor outcome(MRs≥3).Results The poor outcome group showed higher levels of 4-HNE,8-oxo-dG,hepcidin,and TfR,but lower NfL(P<0.05).The ferroptosis score model was constructed by multiple regression analysis,and the results showed that the model can be used as an independent index to predict the adverse prognosis of AIS.Conclusions The ferroptosis model score based on 4-HNE,8-oxo-dG and hepcidin,as well as HGI were closely related to the adverse outcomes of AIS patients,and had a certain value in predicting short-term prognosis.关键词
铁死亡/铁蛋白/空腹血糖/糖化血红蛋白指数/急性缺血性脑卒中/预后模型Key words
ferroptosis/ferritin/fasting blood glucose/hemoglobin glycation index/acute ischemic stroke/prognosis model分类
医药卫生引用本文复制引用
王雁飞,马娟,赵璐..基于外周血铁代谢相关指标的铁死亡积分和HGI对AIS预后评估价值分析[J].兰州大学学报（医学版）,2026,52(5):55-61,7.基金项目
陕西省卫生健康委员会科研项目(20221072) （20221072）
西安市卫生健康委员会中医药科研项目(SZL202405) （SZL202405）
