兰州大学学报（医学版）2026，Vol.52Issue(5)：62-68,7.DOI:10.13885/j.issn.2097-681X.T20260044
甲状腺切除术与常见精神疾病之间的因果关系:一项孟德尔随机化研究
Causal relationship between common psychiatric disorders and thyroidectomy:a Mendelian randomization study
摘要
Abstract
Objective To investigate whether there exists a potential causal association between thyroid-ectomy and nine common psychiatric disorders using a two-sample Mendelian randomization approach.Methods Single nucleotide polymorphisms significantly associated with thyroidectomy(P<5×10-8)were identified from publicly available genome-wide association studies and employed as instrumental variables.To enhance the robustness of the findings,the exposure data underwent secondary standardization.The inverse-variance weighted method was used as the primary analytical approach to evaluate the association between thyroidectomy and nine common mental disorders.Subsequently,heterogeneity and horizontal pleiot-ropy were assessed through sensitivity analyses.Results The inverse-variance weighted analysis revealed that thyroidectomy was not significantly associated with an increased risk of any of the nine psychiatric disor-ders examined,including major depressive disorder,bipolar disorder,and schizophrenia(P>0.05).The results from other Mendelian randomization methods were generally consistent with those obtained from the inverse-variance weighted analysis.Conclusion No clear causal evidence was found between thyroidectomy and the nine common psychiatric disorders analyzed.关键词
精神疾病/重型抑郁障碍/双相情感障碍/精神分裂症/甲状腺切除术/孟德尔随机化研究Key words
mental disorder/major depressive disorder/bipolar disorder/schizophrenia/thyroidectomy/Men-delian randomization study分类
医药卫生引用本文复制引用
张俊平,朱梦娅,郝泽锦,易琬婷,陈宇杭,徐积兄..甲状腺切除术与常见精神疾病之间的因果关系:一项孟德尔随机化研究[J].兰州大学学报（医学版）,2026,52(5):62-68,7.基金项目
国家自然科学基金资助项目(82460168) （82460168）
