临床与实验病理学杂志2026，Vol.42Issue(7)：856-864,9.DOI:10.13315/j.cnki.cjcep.2026.07.003
弥漫大B细胞淋巴瘤中SUMO2的表达及与预后的相关性分析
SUMO2 expression in diffuse large B-cell lymphoma and its association with prog-nosis
摘要
Abstract
Objective To investigate SUMO2 expression in diffuse large B-cell lymphoma(DLBCL)and its asso-ciation with prognosis.Methods Bioinformatics analyses based on the GEPIA2 and GEO public databases were per-formed to compare SUMO2 expression between DLBCL tissues and control tissues with reactive lymphoid hyperplasia and to evaluate the association between SUMO2 expression and overall survival.Paraffin-embedded tissue samples from 145 patients with DLBCL and 43 controls with reactive lymphoid hyperplasia were collected.SUMO2 protein ex-pression was detected by immunohistochemistry,and its associations with clinicopathological characteristics and prog-nosis were analyzed.Univariate and multivariate Cox regression models were used to identify risk factors for poor prog-nosis in patients with DLBCL.Results GEPIA2 data showed that SUMO2 mRNA expression was significantly higher in DLBCL tissues(median,302.375)than in control tissues(median,42.739,P<0.01).The rate of high SUMO2 protein expression was 63.44%(92/145)in DLBCL tissues and 32.56%(14/43)in control tissues.The SUMO2 H-score was significantly higher in the DLBCL group than in the control group(t=4.619,P<0.001).In the GEO data-base,SUMO2 mRNA expression was significantly associated with Hans subtype,lactate dehydrogenase level,and prognosis(P<0.05).In the clinical samples,SUMO2 protein expression was significantly associated with BCL2 gene,MYC protein expression,MYC/BCL2 protein coexpression,and prognosis(P<0.05).Overall survival was sig-nificantly shorter in patients with high SUMO2 mRNA expression than in those with low expression in the GEO data-base(P<0.01).Similarly,overall survival was significantly shorter in patients with high SUMO2 protein expression than in those with low expression in the clinical cohort(P<0.01).Univariate and multivariate Cox regression analy-ses showed that high SUMO2 expression was an independent risk factor for poor prognosis in patients with DLBCL(HR=2.310,95%CI:1.347-3.961,P<0.01).Conclusion SUMO2 expression is upregulated in DLBCL tis-sues,and high SUMO2 expression is an independent risk factor for poor prognosis in patients with DLBCL.关键词
弥漫大B细胞淋巴瘤/SUMO2/预后/BCL2/MYCKey words
diffuse large B-cell lymphoma/SUMO2/prognosis/BCL2/MYC分类
医药卫生引用本文复制引用
于倩倩,孙润哲,李怡静,孟永盛,刘美林,王海珍,孙瑞芳..弥漫大B细胞淋巴瘤中SUMO2的表达及与预后的相关性分析[J].临床与实验病理学杂志,2026,42(7):856-864,9.基金项目
山西省基础研究计划(202203021222383)、山西省肿瘤医院区域医疗中心科教培育基金(SD2023006) Fundamental Research Program of Shanxi Province(202203021222383) （202203021222383）
the Science and Education Cultivation Fund of the National Cancer and Regional Medical Center of Shanxi Provincial Cancer Hospital(SD2023006) （SD2023006）
