临床与实验病理学杂志2026，Vol.42Issue(7)：893-898,6.DOI:10.13315/j.cnki.cjcep.2026.07.008
尿路上皮淋巴上皮瘤样癌16例临床病理分析
Lymphoepithelioma-like urothelial carcinoma:clinicopathological features of 16 cases
周睿 1宋子玉 1陈以明 1刘强1
作者信息
- 1. 上海交通大学医学院附属仁济医院病理科,上海 200127
- 折叠
摘要
Abstract
Objective To investigate the clinicopathological features and prognosis of lymphoepithelioma-like urothelial carcinoma(LELUC),so as to deepen the recognition of this tumor and optimize its diagnosis and treatment regimens.Methods Clinicopathological data of 16 patients diagnosed with LELUC were collected.EnVision immuno-histochemical staining and next-generation sequencing(NGS)were performed,followed by patient follow-up and a sys-tematic review of relevant literature.Results LELUC arose in the upper urinary tract and bladder,with a key histo-logical characteristic of prominent stromal lymphocyte infiltration.Immunohistochemistry showed basal-like differentia-tion in 62.5%(10/16)of the tumors.Tumors exhibited high expression of PD-L1,with a tumor proportion score(TPS)of 10%-80%and a combined positive score(CPS)of 20-100.Among them,62.5%(10/16)of the cases had a CPS of≥50.In addition,mutant-type p53 positivity was observed in 87.5%(14/16)of cases,and all cases demon-strated intact expression of mismatch repair(MMR)proteins.NGS testing of 2 cases with upper urinary tract LELUC identified TP53 mutations in both cases,with tumor mutation burden(TMB)of 3.0 mut/Mb and 13.0 mut/Mb,re-spectively.During a follow-up of 4-90 months,only 2 cases developed tumor recurrence,and no tumor-related death occurred.Conclusion LELUC exhibits distinctive histopathological features,immunophenotypic profiles,and mo-lecular genetic alterations.Conventional treatment combined with immune checkpoint inhibitors may improve the prog-nosis of patients with LELUC.关键词
尿路上皮癌/淋巴上皮瘤样癌/基底样型/PD-L1/TP53突变Key words
urothelial carcinoma/lymphoepithelioma-like carcinoma/basal-like subtype/PD-L1/TP53 mutation分类
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周睿,宋子玉,陈以明,刘强..尿路上皮淋巴上皮瘤样癌16例临床病理分析[J].临床与实验病理学杂志,2026,42(7):893-898,6.
