辽宁中医药大学学报2026，Vol.28Issue(8)：30-36,7.DOI:10.13194/j.issn.1673-842X.2026.08.006
白芍治疗神经病理性疼痛抑郁共病药理机制研究
Research on Pharmacological Mechanism of Baishao(Paeoniae Radix Alba)in the Treatment of Neuropathic Pain and Depression
摘要
Abstract
Neuropathic pain(NP)and major depressive disorder(MDD)are both clinically high morbidity diseases,which are often accompanied by the formation of common diseases,which seriously affect the physical and mental health of patients,but the existing treatments are ineffective and have adverse reactions to some patients.Traditional Chinese medicine has a long history and good effect in the treatment of pain and depression.In traditional Chinese medicine,NP is classified as"pain syndrome"and MDD as"depression syndrome".It is considered that both of them are closely related to the poor operation of Qi and blood.Traditional Chinese medicine Baishao(Paeoniae Radix Alba)has many effects such as nourishing blood and regulating menstruation,softening liver and relieving pain.It can be widely used in the treatment of pain and depression by regulating Qi and promoting blood circulation,soothing liver and relieving depression and other methods.Modern pharmacological studies have further revealed that Baishao(Paeoniae Radix Alba)can effectively treat neuropathic pain and depression through multiple mechanisms such as anti-inflammation,antioxidant stress,nerve repair and neurotransmitter regulation.This paper systematically reviews the relevant literature and research on the treatment of neuropathic pain and depression with Baishao(Paeoniae Radix Alba)in recent years,and deeply discusses the feasibility of Baishao(Paeoniae Radix Alba)and its active components in intervening neuropathic pain and depression through multi-targets and multi-pathways.the purpose of this study is to provide scientific theoretical basis and practical reference for the treatment of neuropathic pain and depression with traditional Chinese medicine.关键词
神经病理性疼痛/抑郁/白芍/共病Key words
neuropathic pain/depression/Baishao(Paeoniae Radix Alba)/comorbidity分类
医药卫生引用本文复制引用
赵晓燕,张慧,张璇,王贤东..白芍治疗神经病理性疼痛抑郁共病药理机制研究[J].辽宁中医药大学学报,2026,28(8):30-36,7.基金项目
国家重点研发计划项目(2020YFC2006904) （2020YFC2006904）
陕西省自然科学基础研究计划项目(2023-JC-QN-0957) （2023-JC-QN-0957）
咸阳市科技局秦创原中医药产业创新聚集区项目(L2024-QCY-ZYYJJQ-X90,L2024-QCY-ZYYJJQ-Y15,L2024-QCY-ZYYJJQ-Y04) （L2024-QCY-ZYYJJQ-X90,L2024-QCY-ZYYJJQ-Y15,L2024-QCY-ZYYJJQ-Y04）
陕西中医药大学研究生教育教学改革创新项目(JGCX001) （JGCX001）
