南京医科大学学报（自然科学版）2026，Vol.46Issue(8)：1131-1136,6.DOI:10.7655/NYDXBNSN251443
哥本哈根指数对超声O-RADS分类及IOTA简单法则诊断附件良恶性肿块的附加价值
The added value of Copenhagen index to O-RADS and IOTA simple rules in the diagnosis of adnexal masses
摘要
Abstract
Objective:To explore the added value of the Copenhagen index(CPH-I)in the diagnosis of adnexal masses with ovarian-adnexal reports and data systems(O-RADS)and the International Ovarian Tumor Analysis(IOTA)simple rules.Methods:The ultrasound images of 179 adnexal masses confirmed by pathological results were analyzed retrospectively in the First People's Hospital of Chuzhou,Anhui from October 2023 to October 2025.The O-RADS classification and IOTA simple rule were used for classification evaluation respectively,and CPH-I of each patient was calculated.Using pathological results as the gold standard,the optimal cutoff value for each diagnostic method was obtained by Youden index.The diagnostic efficacy of the two ultrasound models alone and in combination with CPH-I was compared.The diagnostic efficacy of O-RADS 4 masses and IOTA uncertain masses combined with CPH-I was calculated,too.Delong test was used to compare the area under the curve(AUC)of receiver operating characteristic curve for each model.Results:The optimal cutoff value for O-RADS diagnosis was O-RADS 4 tumors,the optimal cutoff value for IOTA simple rule diagnosis was uncertain masses,and the optimal cutoff value for CPH-I diagnosis was-2.165.The AUC values of O-RADS,IOTA simple rules,and CPH-I for the diagnosis of adnexal masses were 0.866,0.926 and 0.886,respectively.The AUC values of the two ultrasound models combined with CPH-I were 0.861 and 0.902,respectively.When CPH-I was applied separately to O-RADS 4 masses and IOTA uncertain masses,the AUC were 0.933 and 0.941,respectively,which were higher than those of O-RADS and IOTA simple rules alone(P=0.022,P=0.562).Conclusion:CPH-I has good added value to O-RADS and IOTA simple rules in diagnosing adnexal masses,especially when applied to O-RADS 4 masses and IOTA uncertain masses,which were with the best diagnostic performance.关键词
超声诊断/附件肿块/哥本哈根指数/卵巢-附件影像报告和数据系统/国际卵巢肿瘤研究组简单法则Key words
ultrasonography/adnexal masses/Copenhagen index/O-RADS/IOTA simple rule分类
医药卫生引用本文复制引用
姜永玲,周建,陈丽娟,李奥,胡彧..哥本哈根指数对超声O-RADS分类及IOTA简单法则诊断附件良恶性肿块的附加价值[J].南京医科大学学报（自然科学版）,2026,46(8):1131-1136,6.基金项目
国家自然科学基金(82371979) （82371979）
南京市博士后基金(2024BHS201) （2024BHS201）
滁州市卫生健康科研项目(CZWJ2024C007) （CZWJ2024C007）
