南京医科大学学报（自然科学版）2026，Vol.46Issue(8)：1165-1174,1210,11.DOI:10.7655/NYDXBNSN260299
铁死亡在结直肠癌三级预防的应用
Application of ferroptosis in the tertiary prevention of colorectal cancer
摘要
Abstract
Colorectal cancer(CRC)is a common malignancy of the digestive system.Although multimodal treatment strategies have effectively prolonged patient survival,the prognosis of patients with advanced disease remains poor.Therefore,standardizing tertiary prevention of CRC is of great importance.The tertiary prevention strategies for CRC include:primary cause prevention,secondary early prevention,and tertiary clinical prevention.Ferroptosis,a new form of cell death characterized by the accumulation of intracellular iron ions and abnormal aggregation of lipid peroxides,has been exploited in the development of molecular targeted therapies for a variety of common cancers,including CRC.Therefore,investigating the regulatory mechanisms of ferroptosis in CRC and exploring its theoretical basis and emerging strategies within the framework of tertiary prevention can provide additional decision-making tools for cancer prevention and treatment.关键词
铁死亡/结直肠癌/调控机制/三级预防Key words
ferroptosis/colorectal cancer/regulatory mechanism/tertiary prevention分类
医药卫生引用本文复制引用
张靖宇,翁子睿,邓雪婷,缪林..铁死亡在结直肠癌三级预防的应用[J].南京医科大学学报（自然科学版）,2026,46(8):1165-1174,1210,11.基金项目
江苏省中医药科技发展计划项目(2023ZD202328) （2023ZD202328）
