内蒙古民族大学学报（自然科学版）2026，Vol.41Issue(4)：9-16,8.DOI:10.14045/j.cnki.15-1220.2026.04.002
乙型肝炎相关性肝细胞癌枢纽基因及靶向药物的筛选
Screening of Hub Genes and Targeted Drugs for Hepatitis B-Related Hepatocellular Carcinoma
摘要
Abstract
According to statistics from the National Cancer Center of China,hepatocellular carcinoma(HCC)ranks fourth in incidence and second in mortality among all malignant tumors in China.Patients with hepatitis B virus(HBV)infection are classified as a high-risk population for HCC;however,the pathogenesis of HBV-related HCC remains in-completely understood.Elucidating the underlying mechanisms and identifying effective targeted agents are of great sig-nificance for the diagnosis and treatment of this disease.In this study,bioinformatics approaches were employed to screen key targets associated with HBV-related HCC,and reverse network pharmacology analysis was subsequently ap-plied to predict potential therapeutic drugs corresponding to these targets,to provide a bioinformatics-based theoretical foundation for personalized and precision treatment of HBV-related HCC patients.关键词
肝细胞癌/乙型肝炎/TCGA/GO/KEGG分析Key words
hepatocellular carcinoma/hepatitis B/TCGA/GO/KEGG analysis分类
医药卫生引用本文复制引用
张浩,张程..乙型肝炎相关性肝细胞癌枢纽基因及靶向药物的筛选[J].内蒙古民族大学学报（自然科学版）,2026,41(4):9-16,8.基金项目
辽宁省教育厅青年项目(JYTQN2023246) （JYTQN2023246）
