热带亚热带植物学报2026，Vol.34Issue(4)：454-460,7.DOI:10.11926/jtsb.5057
重唇石斛根的化学成分及其生物活性研究
Chemical Constituents from Roots of Dendrobium hercoglossum(Orchidaceae)and Their Biological Activities
摘要
Abstract
To investigate the chemical constituents of the roots of Dendrobium hercoglossum and evaluate their biological activities,the ethyl acetate fraction of an ethanol extract from its roots was isolated and purified by using chromatographic techniques,including silica gel column chromatography and semi-preparative HPLC.The structures of the isolated compounds were elucidated through mass spectrometry and nuclear magnetic resonance spectroscopy(NMR),and then they were subsequently evaluated for anti-inflammatory and other biological activities.The results showed that eight compounds were isolated,such as(Z)-dimethomorph(1),(E)-dimethomorph(2),dengibsin(3),4-O-demethyl-nobilone(4),dendroflorin(5),p-hydroxyphenylpropionic acid(6),syringic acid(7),1H-indole-3-carbaldehyde(8).Compound 4 significantly inhibited LPS-induced NO production in RAW264.7 mouse macrophages,with an IC₅₀ value of(14.69±1.16)μmol/L.Compounds 1 and 2 were isolated as natural products for the first time,as well as their NMR data.Compounds 1-8 were isolated from D.hercoglossum for the first time.Compound 4 showed significant anti-inflammatory activity.关键词
石斛属/重唇石斛/化学成分/抗炎活性Key words
Dendrobium/D.hercoglossum/Chemical constituents/Anti-inflammatory activity引用本文复制引用
马小迪,蔡彩虹,王昊,吴妃,郭东昇,李桂琳,戴好富,周欣,陈惠琴..重唇石斛根的化学成分及其生物活性研究[J].热带亚热带植物学报,2026,34(4):454-460,7.基金项目
海南省自然科学基金青年基金项目(224QN316) （224QN316）
国家中药材产业技术体系项目(CARS-21) （CARS-21）
云南省专家工作站项目(202405AF140026) （202405AF140026）
海南省孙汉董院士工作站基金项目资助 This work was supported by the Project for Natural Science in Hainan(Grant No.224QN316),the Project for Industrial Technology System of Chinese Herbal Medicines(Grant No.CARS-21),the Project for Expert Workstation in Yunnan(Grant No.202405AF140026),the Project of Sun Handong Academician Workstation in Hainan. （Grant No.224QN316）
