四川医学2026，Vol.47Issue(7)：764-770,7.DOI:10.16252/j.cnki.issn1004-0501-2026.07.008
非肥胖人群血浆致动脉粥样硬化指数与糖尿病前期的相关性分析
Correlation Analysis Between Plasma Atherogenic Index and Prediabetes Mellitus in Non-Obese Population
摘要
Abstract
Objective To investigate the relationship between the atherogenic index of plasma(AIP)and prediabetes mellitus(PDM)in non-obese individuals,and to evaluate the predictive value of AIP for PDM.Methods A total of 45,260 non-obese subjects who underwent physical examinations at the Health Management Center of our hospital from January 2021 to December 2024 were enrolled.Subjects were divided into the PDM group and normal glucose tolerance(NG)group according to the WHO diabetes diagnostic criteria.Binary logistic regression model was used to analyze the influencing factors of PDM,and re-ceiver operating characteristic(ROC)curve was employed to assess the predictive value of AIP for PDM.Results ①The preva-lence of PDM was 8.24％,and the AIP level in the PDM group was significantly higher than that in the NG group(P＜0.05).②With the increase of AIP level,the prevalence of PDM gradually increased,and the risk of PDM in males was more prominent in the high AIP state(P＜0.05).③Multivariate logistic regression analysis showed that AIP level was significantly positively correlated with the risk of PDM.After adjusting for all confounding factors,compared with the lowest quartile(Q1),the highest quartile(Q4)of AIP was associated with an 82.4％increased risk of PDM(OR=1.842,95％CI 1.724～1.978,P＜0.001).Male gender,age,systolic blood pressure(SBP),body mass index(BMI),alanine aminotransferase(ALT),aspartate aminotransferase(AST),gam-ma-glutamyl transferase(GGT),albumin(ALB),blood urea nitrogen(BUN),triglycerides(TG),fasting blood glucose(FBG),glycated hemoglobin(HbA1c),and AIP were independent risk factors for PDM,while apolipoprotein A(ApoA)was an independ-ent protective factor.④ROC curve analysis showed that the area under the curve(AUC)of AIP for predicting PDM was 0.729(95％CI 0.720～0.738,P＜0.05),with the optimal diagnostic cutoff value of-0.064.Conclusion AIP is an independent risk factor for PDM in non-obese physical examination populations and has certain predictive value for PDM.ApoA is an independent protective factor for PDM in this population.关键词
糖尿病前期/血浆致动脉粥样硬化指数/非肥胖人群/低密度脂蛋白胆固醇Key words
prediabetes/atherogenic index of plasma/non-obese population/normal LDL cholesterol分类
医药卫生引用本文复制引用
周小燕,杨丹,张敏,王冠,李芸..非肥胖人群血浆致动脉粥样硬化指数与糖尿病前期的相关性分析[J].四川医学,2026,47(7):764-770,7.基金项目
南充市社会科学研究"十五五"规划2026年度项目(编号:NC26B322) （编号:NC26B322）
