山东科学2026，Vol.39Issue(4)：20-26,7.DOI:10.3976/j.issn.1002-4026.2025078
复方石崖茶抑菌搽剂体外抑菌作用及皮肤安全性研究
Study on the in vitro antibacterial effects and skin safety of Compound Shiyacha Antibacterial Liniment
摘要
Abstract
This study evaluated the antibacterial activity of Compound Shiyacha Antibacterial Liniment and its safety on animal skin to provide evidence for its safe clinical use.The agar diffusion method was used to measure inhibition zone diameters against Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,and Candida albicans.The minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)were determined using the double dilution method.Skin safety and sensitization tests were conducted on rats.The results showed that Compound Shiyacha Antibacterial Liniment exhibited strong inhibitory effects against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,and Candida albicans,with the strongest antibacterial activity observed against Staphylococcus aureus(inhibition zone diameter:29.1 mm;MIC:1.562 5 mg/mL;MBC:3.125 mg/ml).The liniment caused no skin irritation or sensitization reactions in rats,demonstrating good safety.It may serve as a potential alternative to traditional antibacterial drugs and may be suitable for preventing and treating skin infections in sensitive populations.关键词
石崖茶/抑菌/皮肤安全性/民族药Key words
Adinandra nitida Merr.ex Li/antibacterial/skin safety/ethnomedicine分类
医药卫生引用本文复制引用
刘钰,陈路,黄丹娜,潘宇,邓日建,徐永莉,赵成坚,肖璐,张宇深,吴无畏..复方石崖茶抑菌搽剂体外抑菌作用及皮肤安全性研究[J].山东科学,2026,39(4):20-26,7.基金项目
四川省区域创新合作项目(2025YFHZ0307) （2025YFHZ0307）
广西产学研科学研究重点课题(guirzdkt2025-14) （guirzdkt2025-14）
广西食品安全地方标准制修订项目(桂地标食2022008) （桂地标食2022008）
