药学研究2026，Vol.45Issue(7)：729-733,751,6.DOI:10.13506/j.cnki.jpr.2026.07.002
青藤碱对大鼠肺动脉高压的治疗作用及其关键信号通路分析
The therapeutic effect of sinomenine on pulmonary arterial hypertension in rats and analysis of its key signaling pathways
摘要
Abstract
Objective To explore the preventive and therapeutic effects of sinomenine(SIN)on monocrotaline(MCT)-induced pulmonary arterial hypertension(PAH)in rats,as well as its potential regulatory signaling pathways.Methods A rat model of PAH was established via MCT induction.Right heart catheterization was performed to measure the right ventricular systolic pressure(RVSP)in rats.High-throughput sequencing technology was used to analyze the gene expression profile of rat lung tissues,and enrichment analysis was employed to screen the key signaling pathways through which SIN ameliorates MCT-induced PAH in rats.Finally,quantitative real-time polymerase chain reaction(qRT-PCR)was utilized to detect the expression of core genes in the identified pathways.Results SIN significantly inhibited the MCT-induced increase in RVSP and thickness of pulmonary arterial vessels in rats.Analysis of lung tissue transcriptome data and detection of pulmonary arterial vascular genes revealed that SIN might ameliorate MCT-induced PAH in rats by inhibiting the extracellular matrix(ECM)-receptor interaction signaling pathway.Conclusion SIN may ameliorate MCT-induced PAH in rats by inhibiting the ECM-receptor interaction signaling pathway.关键词
青藤碱/肺动脉高压/胞外基质/信号通路Key words
Sinomenine/Pulmonary arterial hypertension/Extracellular matrix/Signaling pathway分类
医药卫生引用本文复制引用
陈子怡,黄小阳,曾振华,唐日红,吴卫华..青藤碱对大鼠肺动脉高压的治疗作用及其关键信号通路分析[J].药学研究,2026,45(7):729-733,751,6.基金项目
湖南省自然科学基金区域联合项目(No.2025JJ70468) （No.2025JJ70468）
湖南省教育厅科学研究项目(No.23B1052、23A0720) （No.23B1052、23A0720）
