青少年非自杀性自伤的磁共振成像研究进展
Advances in Magnetic Resonance Imaging Research on Adolescent Non-suicidal Self-injury
摘要
Abstract
Non-suicidal self-injury(NSSI)is a common high-risk behavior among adolescents and is closely associated with emotion regulation difficulties,increased suicide risk,and a range of psychiatric disorders.In recent years,advances in magnetic resonance imaging(MRI)have provided important tools for elucidating the neurobiological mechanisms underlying adolescent NSSI.This review summarizes neuroimaging evidence related to adolescent NSSI,with a focus on structural magnetic resonance imaging(sMRI)and functional magnetic resonance imaging(fMRI)studies.Existing evidence suggests that adolescents with NSSI show gray matter structural abnormalities and impaired white matter integrity in the anterior cingulate cortex,insula,frontal and temporal regions,as well as reward-related brain areas.Resting-state and task-based fMRI studies have further identified abnormal functional connectivity and neural activation in brain networks associated with emotion processing,pain regulation,reward processing,social cognition,and executive control.In addition,multimodal studies suggest that disrupted structure-function coupling may represent an important neural mechanism of NSSI.However,current research is limited by relatively small sample sizes,the predominance of cross-sectional designs,difficulties in controlling for psychiatric comorbidities,and substantial heterogeneity in analytical methods.Future studies should employ large-scale,multicenter,longitudinal,and multimodal approaches to identify stable and reliable neuroimaging biomarkers,thereby providing a neurobiological basis for the early identification,risk assessment,and precision intervention of adolescent NSSI.关键词
非自杀性自伤/青少年精神健康/脑磁共振成像/结构磁共振成像/功能磁共振成像/神经影像学Key words
non-suicidal self-injury(NSSI)/adolescent mental health/magnetic resonance imaging(MRI)/structural MRI(sMRI)/functional MRI(fMRI)/neuroimaging分类
医药卫生引用本文复制引用
梁臻,钟书婷,徐颖,黄怡,张力,黄淦,周勇杰..青少年非自杀性自伤的磁共振成像研究进展[J].数据采集与处理,2026,41(4):946-965,20.基金项目
国家自然科学基金(62522608) （62522608）
广东省项目(2024TQ08X330) （2024TQ08X330）
国家科技重大专项(2021ZD0200500) （2021ZD0200500）
深港脑科学创新研究院-深圳市基础研究机构项目(2023SHIBS0003) （2023SHIBS0003）
深圳市科技计划项目(JCYJ20241202124222027,JCYJ20241202124209011) （JCYJ20241202124222027,JCYJ20241202124209011）
深圳大学医工交叉研究基金(2024YG008) （2024YG008）
湖南省重点研发计划项目(2025QK3008). National Natural Science Foundation of China(No.62522608) （2025QK3008）
Guangdong Provincial Project(No.2024TQ08X330) （No.2024TQ08X330）
Science and Technology Innovation 2030—Major Projects(No.2021ZD0200500) （No.2021ZD0200500）
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Basic Research Institution Program(No.2023SHIBS0003) （No.2023SHIBS0003）
Shenzhen Science and Technology Program(Nos.JCYJ20241202124222027 and JCYJ20241202124209011) （Nos.JCYJ20241202124222027 and JCYJ20241202124209011）
Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University(No.2024YG008) （No.2024YG008）
Hunan Provincial Key Research and Development Program(No.2025QK3008). （No.2025QK3008）
