世界中医药2026，Vol.21Issue(9)：1653-1661,9.DOI:10.3969/j.issn.1673-7202.2026.09.007
深海龙胶囊对少弱精症动物模型的药效研究
Pharmacodynamic Effects of Shenhailong Capsules on Animal Models of Oligoasthenospermia
摘要
Abstract
Objective:To evaluate the therapeutic effects of Shenhailong Capsules on animal models of oligoasthenospermia in-duced by four drugs.Methods:Oligoasthenospermia animal models were established by feeding rats with adenine(200 mg/kg),tripterygium glycosides(50 mg/kg),or ornidazole(800 mg/kg)by gavage for 28 days,and by intraperitoneal injection of cyclo-phosphamide(50 m g/kg)in mice for 7 days.Rats were subsequently administered with Shenhailong Capsules by gavage at doses of 0.28,0.56,and 1.12 g/kg,and mice at doses of 0.45,0.90,and 1.80 g/kg for 28 days.The weights and organ coefficients of the testes and epididymides were measured.The proportion of progressively motile sperm,motile sperm rate,sperm count,and sperm de-formity rate were assessed.Serum levels of testosterone(T),estradiol(E2),follicle-stimulating hormone(FSH),and luteinizing hor-mone(LH)were determined by enzyme-linked immunosorbent assay(ELISA).Histopathological changes in the testes and epididy-mides were observed using hematoxylin-eosin(HE)staining.Results:Shenhailong Capsules showed significant improvement in all four drug-induced oligoasthenospermia models.The treatment dose-dependently increased the weights and organ coefficients of the testes and epididymides,increased sperm count,improved sperm motility,and reduced sperm deformity rate.Serum T levels were in-creased,while serum E2,FSH,and LH levels were decreased.In addition,histopathological damage in the testes and epididymides was effectively improved.Conclusion:Shenhailong Capsules exert therapeutic effects in four different drug-induced oligoastheno-spermia animal models.关键词
深海龙胶囊/少弱精症/腺嘌呤/雷公藤多苷/奥硝唑/环磷酰胺/大鼠模型/小鼠模型Key words
Shenhailong Capsules/Oligoasthenospermia/Adenine/Tripterygium glycosides/Ornidazole/Cyclophosphamide/Rat model/Mouse model分类
医药卫生引用本文复制引用
潘嘉,张力涵,梁媛媛,刘洁,尹静,刘佳桐,张培海,张蜀武..深海龙胶囊对少弱精症动物模型的药效研究[J].世界中医药,2026,21(9):1653-1661,9.基金项目
全国名老中医药专家张蜀武传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
四川省中医药管理局科学技术研究专项课题(2023MS098). （2023MS098）
