生物骨科材料与临床研究2026，Vol.23Issue(4)：7-11,5.DOI:10.3969/j.issn.1672-5972.2026.04.002
不同平面冲击波治疗对兔糖尿病足溃疡创面愈合的影响
Effects of extracorporeal shock wave therapy in different planes on wound healing of diabetic foot ulcer in rabbits
摘要
Abstract
Objective To investigate the effects of extracorporeal shock waves applied in different planes on the healing of diabetic foot ulcer wounds in rabbits.Methods Forty New Zealand white rabbits weighing 2-3 kg were selected to establish a diabetic foot ulcer model through high-fat feeding,intravenous injection of alloxan solution,and femoral artery ligation.The rabbits were randomly divided into four groups(n=10):a model group,a shock wave therapy group 1(SWT1)receiving extracorporeal shock waves at the proximal end of the affected limb,a shock wave therapy group 2(SWT2)receiving shock waves around the wound,and a shock wave therapy group 3(SWT3)receiving extracorporeal shock waves at both the proximal end of the affected limb and around the wound.Treatment was administered twice a week for four weeks.Changes in wound healing,blood glucose levels,and body temperature of the affected limb in the rabbits were measured.Results Compared with the other groups,the SWT2 and SWT3 groups showed significant improvements in ulcer healing and a marked increase in the body temperature of the affected limb(P<0.05).There were no significant changes in blood glucose levels among the groups(P>0.05).Conclusion Extracorporeal shock wave therapy can promote the healing of diabetic foot ulcers.More importantly,the combination of shock waves applied around the wound and at the proximal end of the affected limb yields better therapeutic outcomes than localized treatment alone.关键词
糖尿病足溃疡/体外冲击波治疗/伤口愈合/糖尿病Key words
Diabetic foot ulcer/Extracorporeal shock wave therapy/Wound healing/Diabetes分类
医药卫生引用本文复制引用
王莲朋,王文琦,蒋凌霄,穆合塔尔·伊马木尼亚孜,王浩越,薛恩涛,方继悦,韩亚军..不同平面冲击波治疗对兔糖尿病足溃疡创面愈合的影响[J].生物骨科材料与临床研究,2026,23(4):7-11,5.基金项目
新疆神经系统疾病研究重点实验室开放课题项目(XJDX1711-2402) （XJDX1711-2402）
