护理研究2026，Vol.40Issue(16)：2790-2796,7.DOI:10.12102/j.issn.1009-6493.2026.16.004
幽门螺杆菌感染对成人同型半胱氨酸水平及脉搏波传导速度的影响
Effect of helicobacter pylori infection on adult homocysteine level and pulse wave velocity
摘要
Abstract
Objective:To investigate the association between helicobacter pylori infection and serum homocysteine(Hcy)levels as well as brachial-ankle pulse wave velocity(baPWV),and to assess whether helicobacter pylori infection is an independent risk factor for hyperhomocysteinemia and arterial stiffness.Methods:A total of 6 207 adults who underwent physical examinations at our hospital from January 2022 to December 2023 were included.The subjects were divided into the helicobacter pylori positive group and the helicobacter pylori negative group based on the results of the 13C urea breath test.Linear regression analysis was used to evaluate the linear association between helicobacter pylori infection and Hcy as well as baPWV.Further,multivariate logistic regression was employed to construct models for high Hcy(≥15 μmol/L)and high baPWV(≥1 800 cm/s),and sensitivity analysis was conducted.Results:There was no significant linear correlation between helicobacter pylori infection and Hcy or baPWV.High Hcy increased the risk of helicobacter pylori positive individuals(P<0.001),and the risk of having high baPWV was significantly increased(P<0.001).The results of the sensitivity analysis were consistent.Conclusions:There is no significant linear correlation between helicobacter pylori infection and Hcy or baPWV.However,helicobacter pylori infection significantly increases the risk of high Hcy levels and arterial stiffness.Helicobacter pylori infection may affect vascular elasticity through inflammatory responses,nutrient absorption disorders,or metabolic pathways.关键词
幽门螺杆菌/同型半胱氨酸/脉搏波传播速度/动脉僵硬度/多变量回归Key words
helicobacter pylori/homocysteine/pulse wave velocity/arterial stiffness/multivariate regression引用本文复制引用
王丹,勇琴歌,郭亮梅,卿华,孙宁,马聪..幽门螺杆菌感染对成人同型半胱氨酸水平及脉搏波传导速度的影响[J].护理研究,2026,40(16):2790-2796,7.基金项目
国家老年疾病临床医学研究中心开放课题资助项目,编号:NCRCG-PLAGH-2024014 （）
