陕西医学杂志2026，Vol.55Issue(8)：1070-1074,5.DOI:10.3969/j.issn.1000-7377.2026.08.009
血清雌二醇、骨密度对绝经后脊柱退行性疾病患者术后预后不良的预测价值
Predictive value of serum estradiol and bone mineral density for poor postoperative prognosis in postmenopausal patients with degenerative spinal diseases
摘要
Abstract
Objective:To investigate the predictive value of serum estradiol(E2)and bone mineral density(BMD)for poor postoperative prognosis in postmenopausal patients with degenerative spinal diseases.Methods:A to-tal of 186 postmenopausal patients with degenerative spinal diseases who received surgical treatment were enrolled.According to the Oswestry Disability Index(ODI)score at 12 months after surgery,patients were divided into the good prognosis group(ODI≤20 points,112 cases)and the poor prognosis group(ODI＞20 points,74 cases).Clinical data,serum E2 levels,lumbar BMD and hip BMD were compared between the two groups.Multivariate Logistic re-gression analysis was performed to identify the influencing factors of poor postoperative prognosis in postmenopausal patients with degenerative spinal diseases.ROC curves were plotted,and the AUC was calculated to evaluate the pre-dictive value of serum E2,lumbar BMD and hip BMD for poor postoperative prognosis.Results:There were no statis-tically significant differences in body mass index(BMI),surgical site,operation duration and intraoperative blood loss between the two groups(all P＞0.05).Compared with the good prognosis group,patients in the poor prognosis group were older with longer postmenopausal years,and had higher proportions of ≥3 surgical segments,complex surgical procedures and postoperative sagittal vertical axis(SVA)＞50 mm(all P＜0.05).The serum E2 level,lum-bar BMD T-score and hip BMD T-score in the poor prognosis group were significantly lower than those in the good prognosis group(all P＜0.05).Age,number of surgical segments,surgical approach,postoperative SVA,serum E2,lumbar BMD T-score and hip BMD T-score were independent influencing factors for poor postoperative prognosis in postmenopausal patients with degenerative spinal diseases(all P＜0.05).The AUC of combined detection of serum E2,lumbar BMD T-score and hip BMD T-score for predicting poor postoperative prognosis was higher than that of each single indicator(all P＜0.05).Conclusion:Serum E2,lumbar BMD and hip BMD are influencing factors for poor postoperative prognosis in postmenopausal patients with degenerative spinal diseases,and the combined detection of the three indicators exhibits high predictive value for poor postoperative prognosis.关键词
脊柱退行性疾病/绝经后女性/雌二醇/骨密度/预后/预测价值Key words
Degenerative spinal diseases/Postmenopausal women/Estradiol/Bone mineral density/Prognosis/Predictive value分类
医药卫生引用本文复制引用
王亚芬,韩桃丽,谢晓聪,姚静,马辉,解国辉..血清雌二醇、骨密度对绝经后脊柱退行性疾病患者术后预后不良的预测价值[J].陕西医学杂志,2026,55(8):1070-1074,5.基金项目
山西省重点研发计划项目(2023SXZ-12053) （2023SXZ-12053）
