陕西医学杂志2026，Vol.55Issue(8)：1075-1079,5.DOI:10.3969/j.issn.1000-7377.2026.08.010
神经导航联合荧光素钠染色技术在脑胶质瘤切除术中的应用价值研究
Application value of neuronavigation combined with fluorescein sodium staining technique in glioma resection
摘要
Abstract
Objective:To investigate the clinical application value of neuronavigation combined with fluorescein sodium staining technique in glioma resection.Methods:A total of 106 patients with glioma were selected and ran-domly divided into control group and observation group,with 53 cases in each group.All patients underwent glioma resection.The control group was guided by diffusion tensor imaging(DTI)neuronavigation,and the observation group was treated with DTI-guided neuronavigation combined with intraoperative fluorescein sodium staining tech-nique.The degree of tumor resection,perioperative indicators,cerebrospinal fluid neuropeptide levels and Mini-Mental State Examination(MMSE)scores before surgery and six months after surgery,as well as postoperative complica-tions and survival status were compared between the two groups.Results:The total tumor resection rate and total re-section rate of high-grade glioma in the observation group were higher than those in the control group(all P＜0.05).There was no statistically significant difference in the total resection rate of low-grade glioma between the two groups(P＞0.05).At six months after surgery,the improvement degree of cerebrospinal fluid neuropeptide levels and MMSE scores of each dimension in the observation group was better than that in the control group(all P＜0.05).The operation time,hospital stay and intraoperative blood loss in the observation group were less than those in the control group(all P＜0.05).There were no statistically significant differences in the incidence of postoperative in-tracranial infection,pulmonary infection and epilepsy between the two groups(all P＞0.05).No death cases occurred during the 6-month follow-up.Conclusion:The application of DTI-guided neuronavigation combined with fluorescein sodium staining technique in glioma resection can increase the total resection rate of glioma,shorten operation time,reduce intraoperative blood loss,protect neurological function,improve cognitive function,and does not increase the risk of complications.关键词
脑胶质瘤/神经导航/弥散张量成像/荧光素钠/认知功能/并发症Key words
Glioma/Neuronavigation/Diffusion tensor imaging/Fluorescein sodium/Cognitive function/Complications分类
医药卫生引用本文复制引用
侯庆石,方钦锐,张艳..神经导航联合荧光素钠染色技术在脑胶质瘤切除术中的应用价值研究[J].陕西医学杂志,2026,55(8):1075-1079,5.基金项目
广东省基础与应用基础研究基金资助项目(2023GRZ-120635) （2023GRZ-120635）
